Weight cycling and mortality among middle-aged or older women.
Weight cycling and mortality among middle-aged or older women.
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DOI：
10.1001/archinternmed.2009.67
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发表时间：
2009-05-11
影响因子：
--
通讯作者：
Willett, Walter C.
中科院分区：
文献类型：
--
作者：
Field, Alison E.;Malspeis, Susan;Willett, Walter C.
关于重量自行车是否会增加发病率和死亡率存在争议。评估重量循环与死亡率之间的独立关联。护士健康研究对44,876名中老年妇女进行了前瞻性研究，她们提供了1972年至1992年期间有意减肥的信息，至少存活到1994年，体重指数≥为17公斤/平方米，没有癌症(非黑色素瘤皮肤癌除外)或心脏病病史。报告称自己故意减掉≥20磅至少3次的女性被归类为重度骑自行车者。故意减掉≥磅至少3次，但不符合重度重量自行车标准的女性，被归类为轻度体重自行车者。所有这些都会导致死亡。在1972至1992年间，大约18.8%的女性是轻量级自行车手，8.0%的女性是重度自行车手。在12年的随访中，2882名女性死亡，其中424人死于心血管事件。在随访期内，骑自行车的人比不骑自行车的人增加了更多的体重(p<；0.001)。在调整了18岁时的BMI、体力活动、吸烟、绝经后激素使用、酒精摄入量、18岁后的净体重变化和体力活动变化后，轻度(相对风险[RR]=0.84，95%可信区间[CI]0.75-0.93)或重度骑行者(RR=0.90，95%可信区间0.77-1.04)的风险没有增加。在心血管死亡率和70岁或70岁以下女性中也观察到了类似的结果。反复故意减肥并不能预示更高的全因死亡率或心血管死亡率。
Controversy exists around whether weight cycling increases morbidity and mortality. To assess the independent association of weight cycling with mortality. A prospective study of 44,876 middle-aged and older women in the Nurses' Health Study who provided information on intentional weight losses between 1972 and 1992, survived until at least 1994, had a body mass index ≥17 kg/m2, and had no history of cancer (other than non-melanoma skin cancer) or heart disease. Women who reported they had intentionally lost ≥ 20 lbs at least 3 times were classified as severe weight cyclers. Women who had intentionally lost ≥ lbs at least 3 times, but did not meet the criteria for severe weight cycling, were classified as mild weight cyclers. All cause mortality. Between 1972 and 1992, approximately 18.8% of the women were mild weight cyclers and 8.0% were severe weight cyclers. During 12 years of follow-up 2,882 women died, of their deaths, 424 were due to cardiovascular events. Weight cyclers gained more weight during follow-up than non-cyclers (p <0.001). After adjusting for BMI at age 18, physical activity, smoking, post-menopausal hormone use, alcohol intake, net weight change from age 18, and change in physical activity, there was no increase in risk among mild (relative risk [RR]=0.84, 95% confidence interval [CI] 0.75–0.93) or severe cyclers (RR=0.90, 95% CI 0.77–1.04). Similar results were observed for cardiovascular mortality and among women 70 years of age or less. Repeated intentional weight losses were not predictive of greater all-cause or cardiovascular mortality.
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影响因子：
158.5
作者：
Calle, EE;Thun, MJ;Heath, CW
通讯作者：
Heath, CW
影响因子：
158.5
作者：
LISSNER, L;ODELL, PM;BROWNELL, KD
通讯作者：
BROWNELL, KD
影响因子：
158.5
作者：
MANSON, JE;WILLETT, WC;SPEIZER, FE
通讯作者：
SPEIZER, FE
DOI：
10.7326/0003-4819-119-7_part_2-199310011-00024
发表时间：
1993-10-01
影响因子：
39.2
作者：
BLAIR, SN;SHATEN, J;LISSNER, L
通讯作者：
LISSNER, L
影响因子：
4.9
作者：
Allison, DB;Zannolli, R;Heymsfield, SB
通讯作者：
Heymsfield, SB