Circulating miR-1826 in plasma correlates with circulating tumor cells and is a prognostic marker in colorectal cancer
Circulating miR-1826 in plasma correlates with circulating tumor cells and is a prognostic marker in colorectal cancer
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血浆中的循环 miR-1826 与循环肿瘤细胞相关，是结直肠癌的预后标志物
DOI：
10.1177/1010428317705333
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发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Zhi Qiaoming
中科院分区：
文献类型：
--
作者：
Xu Zhihua;Xi Tianyi;Han Ye;Guo Xiaobo;Liu Fei;Jiang Min;Wan Daiwei;Xue Xiaofeng;He Songbing;Ren Rui;Li Wei;Zhi Qiaoming
我们前期的研究表明，miR-1826是一种新发现的结直肠癌中致癌的非编码RNA。但miR-1826与肿瘤转移之间的潜在关系尚未完全阐明。本研究的目的是评估结直肠癌中循环miR-1826的临床意义及其与循环肿瘤细胞的可能关联。我们的研究结果首先发现，与健康志愿者相比，结直肠癌患者血清miR-1826明显上调（p = 0.003）。在结直肠癌远处转移患者（p = 0.001）和晚期结直肠癌患者（p < 0.001）中也分别发现了类似的结果。临床病理分析提示，循环miR-1826与pT分期（p = 0.026）、淋巴转移（p = 0.034）、远处转移（p = 0.012）、肿瘤-淋巴结转移分期（p = 0.020）呈正相关。此外，我们的单因素和多因素分析表明，血清miR-1826高表达可能是结直肠癌患者总生存的预后和独立因素（p < 0.05），并导致结直肠癌患者5年总生存率较差（p = 0.025）。循环miR-1826曲线下面积高达0.848±0.043，强烈提示血清miR-1826是结直肠癌患者有效的诊断生物标志物（p < 0.001）。我们随后的实验表明，与循环肿瘤细胞阴性的患者相比，循环肿瘤细胞高水平的患者miR-1826表达水平更高（p = 0.011）。相似的结果也显示，高miR-1826组循环肿瘤细胞数量显著高于低miR-1826组（p = 0.001）。采用SPSS软件分析血清miR-1826与循环肿瘤细胞的关系，发现其与结直肠癌患者血清中循环肿瘤细胞的数量呈显著的对数关系，即循环miR-1826与结直肠癌患者血清循环肿瘤细胞数量密切相关（r = 0.283, p < 0.01）。我们的研究结果强烈提示血清miR-1826可作为结直肠癌诊断和预后的有效且无创的生物标志物。循环miR-1826可能是结直肠癌治疗的重要靶点。
Our previous study showed that miR-1826 was a newly identified oncogenic non-coding RNA in colorectal cancer. But the potential relationship between miR-1826 and tumor metastasis has not been fully elucidated. The purpose of this study was to evaluate the clinical significance of circulating miR-1826 and its possible associations with circulating tumor cells in colorectal cancer. Our results first found that serum miR-1826 was significantly upregulated in colorectal cancer patients, compared with that in healthy volunteers (p = 0.003). Similar results were also found in colorectal cancer with distant metastasis (p = 0.001) and advanced colorectal cancer (p < 0.001) patients, respectively. Clinicopathological analysis implied that circulating miR-1826 was positively associated with pT stage (p = 0.026), lymphatic metastasis (p = 0.034), distant metastasis (p = 0.012), and tumor–node–metastasis stage (p = 0.020). Besides, our univariate and multivariate analyses demonstrated that high serum miR-1826 expression could act as a prognostic and independent factor for overall survival of colorectal cancer patients (p < 0.05), which led to a poorer 5-year overall survival rate (p = 0.025). The area under the curve value of circulating miR-1826 was up to 0.848 ± 0.043, which strongly suggested serum miR-1826 as an effective diagnostic biomarker in colorectal cancer patients (p < 0.001). Our subsequent experiments demonstrated that patients with high level of circulating tumor cells showed a higher level of miR-1826 expression, compared with the circulating tumor cell–negative patients (p = 0.011). Similar results also showed that the amount of circulating tumor cells in high miR-1826 group was significantly higher than that in low miR-1826 group (p = 0.001). Furthermore, the relationship between serum miR-1826 and circulating tumor cells was analyzed using SPSS software and a significant logarithmic relationship was found, which meant that circulating miR-1826 closely correlated with the amount of circulating tumor cells in colorectal cancer patient serum (r = 0.283, p < 0.01). Our findings strongly suggested that serum miR-1826 could serve as an effective and non-invasive biomarker for diagnosis and prognosis of colorectal cancer. Circulating miR-1826 may be an important target in colorectal cancer therapy.
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作者：
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通讯作者：
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