Epigenetic control of the Epstein-Barr lifecycle.
Epigenetic control of the Epstein-Barr lifecycle.
复制标题
DOI：
10.1016/j.coviro.2021.11.013
复制
发表时间：
2022-03
影响因子：
5.9
通讯作者：
中科院分区：
文献类型：
--
作者：
Epstein-Barr virus (EBV) infects 95% of adults worldwide, causes infectious mononucleosis, is etiologically linked to multiple sclerosis and is associated with 200 000 cases of cancer each year. EBV manipulates host epigenetic pathways to switch between a series of latency programs and to reactivate from latency in order to colonize the memory B-cell compartment for lifelong infection and to ultimately spread to new hosts. Here, we review recent advances in the understanding of epigenetic mechanisms that control EBV latency and lytic gene expression in EBV-transformed B and epithelial cells. We highlight newly appreciated roles of DNA methylation epigenetic machinery, host histone chaperones, the Hippo pathway, m6A RNA modification and nonsense mediated decay in control of the EBV lifecycle.
登录
查看更多内容
影响因子：
30.8
作者：
Kulis M;Merkel A;Heath S;Queirós AC;Schuyler RP;Castellano G;Beekman R;Raineri E;Esteve A;Clot G;Verdaguer-Dot N;Duran-Ferrer M;Russiñol N;Vilarrasa-Blasi R;Ecker S;Pancaldi V;Rico D;Agueda L;Blanc J;Richardson D;Clarke L;Datta A;Pascual M;Agirre X;Prosper F;Alignani D;Paiva B;Caron G;Fest T;Muench MO;Fomin ME;Lee ST;Wiemels JL;Valencia A;Gut M;Flicek P;Stunnenberg HG;Siebert R;Küppers R;Gut IG;Campo E;Martín-Subero JI
通讯作者：
Martín-Subero JI
影响因子：
6.7
作者：
De Leo A;Chen HS;Hu CC;Lieberman PM
通讯作者：
Lieberman PM
影响因子：
16.6
作者：
Huang, Hongda;Deng, Zhong;Vladimirova, Olga;Wiedmer, Andreas;Lu, Fang;Lieberman, Paul M.;Patel, Dinshaw J.
通讯作者：
Patel, Dinshaw J.
影响因子：
64.5
作者：
Dheekollu J;Wiedmer A;Ayyanathan K;Deakyne JS;Messick TE;Lieberman PM
通讯作者：
Lieberman PM
影响因子：
14.9
作者：
Buschle A;Mrozek-Gorska P;Cernilogar FM;Ettinger A;Pich D;Krebs S;Mocanu B;Blum H;Schotta G;Straub T;Hammerschmidt W
通讯作者：
Hammerschmidt W