Pathological and biological features of mammographically detected invasive breast carcinomas.
Pathological and biological features of mammographically detected invasive breast carcinomas.
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DOI：
10.1038/bjc.1995.31
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发表时间：
1995-01
影响因子：
8.8
通讯作者：
Walker, R. A.
中科院分区：
文献类型：
--
作者：
Rajakariar, R.;Walker, R. A.
一系列连续的不可触及的浸润性乳腺癌的病理学和生物学特征，检测乳房X线摄影在流行的一轮乳房筛查方案，已与临床上提出的年龄匹配的患者的癌症组进行了比较。在乳腺X线摄影检测组中，管状癌作为高分化浸润性导管癌的患病率显著较高，而低分化浸润性导管癌的患病率较低。淋巴结转移率在未触及组为6.5%，而在临床组为53%。未触及组雌激素受体的患病率（96%）远高于对照组（67%），尽管孕激素受体无显著差异。pS2的患病率在未触及组中也高得多，组织蛋白酶D也是如此。考虑到组织蛋白酶D与较差生存率之间的关系，这一发现令人惊讶。p53和c-erb-2蛋白在少数未触及的癌中可检测到。MIBI（Ki-67）指数在未触及组（11.6）低于临床组（15.25）。在乳腺X线检查检测组中，肾小管癌和不同级别的浸润性导管癌之间的MIBI指数存在显著差异，每个类别的范围很广，但与大小无关。乳腺X线摄影检测到的不可触及的癌在许多方面与临床表现的癌不同，这就提出了一个问题，即是否一部分或全部会随着时间的推移而进展（去分化）。
The pathological and biological features of a consecutive series of impalpable invasive breast carcinoma, detected by mammography in the prevalent round of the breast screening programme, have been compared with a clinically presenting group of carcinomas in age-matched patients. There was a significantly higher prevalence of tubular carcinomas as well-differentiated infiltrating ductal carcinomas in the mammographically detected group, and a lower prevalence of poorly differentiated infiltrating ductal carcinomas. Lymph node metastasis was found in 6.5% of the impalpable group compared with 53% of the clinical group. The prevalence of oestrogen receptor was much higher in the impalpable group (96%) than in the control group (67%), although there were no significant differences for progesterone receptor. The prevalence of pS2 was also much higher in the impalpable group, as was cathepsin D. This finding is surprising in view of the reported relationship between cathepsin D and poorer survival. p53 and c-erb-2 proteins were detectable in fewer impalpable carcinomas. The mean MIBI (Ki-67) index was lower in the impalpable group (11.6) than in the clinical group (15.25). Within the mammographically detected group there was a significant difference in the MIBI index between tubular carcinomas and the different grades of infiltrating ductal carcinomas, with a wide range in each category but no association with size. The impalpable carcinomas detected by mammography differ from clinically presenting carcinomas in many ways, raising the question of whether a proportion or all would progress (dedifferentiate) with time.
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影响因子：
3.3
作者：
BARNES, DM;DUBLIN, EA;MILLIS, RR
通讯作者：
MILLIS, RR
影响因子：
8.8
作者：
ANDERSON, TJ;LAMB, J;FORREST, P
通讯作者：
FORREST, P
DOI：
10.1007/bf00496564
发表时间：
1981-01-01
期刊：
VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY
影响因子：
--
作者：
RASMUSSEN, BB;ROSE, C;PALSHOF, T
通讯作者：
PALSHOF, T
影响因子：
6.4
作者：
SOOMRO, S;SHOUSHA, S;SINNETT, HD
通讯作者：
SINNETT, HD
影响因子：
--
作者：
KLEMI, PJ;JOENSUU, H;PARVINEN, I
通讯作者：
PARVINEN, I