Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytes.
Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytes.
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DOI：
10.1002/mnfr.201400631
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发表时间：
2015-04
影响因子：
5.2
通讯作者：
Oteiza, Patricia I.
中科院分区：
文献类型：
--
作者：
Vazquez Prieto, Marcela A.;Bettaieb, Ahmed;Rodriguez Lanzi, Cecilia;Soto, Veronica C.;Perdicaro, Diahann J.;Galmarini, Claudio R.;Haj, Fawaz G.;Miatello, Roberto M.;Oteiza, Patricia I.
本研究评价了饮食中儿茶素(C)、槲皮素(Q)及其组合(CQ)对大鼠高果糖摄入引发的脂肪炎症和肿瘤坏死因子α在3T3-L1脂肪细胞中的抑制作用。在大鼠中，摄入HFR 6wk会导致血脂异常、胰岛素抵抗、血浆脂联素降低、肥胖和脂肪组织炎症。日粮中添加20 mg/kg的C、Q和CQ均能改善上述指标。在3T3-L1脂肪细胞中，C和Q可减弱肿瘤坏死因子α诱导的蛋白羰基的升高，增加促炎细胞因子(单核细胞趋化蛋白-1，抵抗素)的表达，并降低脂联素。C和Q对脂肪炎症的保护作用部分与其以下作用有关：1)减少丝裂原活化蛋白激酶(MAPK)的激活；2)阻止PPARγ的下调。总之，C和Q，以及在更大程度上两者的组合，减弱了脂肪促炎信号的级联，并调节了改善(脂联素)或损害(肿瘤坏死因子α、单核细胞趋化蛋白-1、抵抗素)胰岛素敏感性的分子平衡。总之，这些发现表明，饮食中的Q和C可能在缓解蛋氨酸相关的脂肪炎症、氧化应激和胰岛素抵抗方面有潜在的好处。
This study evaluated the capacity of dietary catechin (C), quercetin (Q) and the combination of both (CQ), to attenuate adipose inflammation triggered by high fructose (HFr) consumption in rats and by tumor necrosis factor alpha (TNFα) in 3T3-L1 adipocytes. In rats, HFr consumption for 6 wk caused dyslipidemia, insulin resistance, reduced plasma adiponectin, adiposity, and adipose tissue inflammation. Dietary supplementation with 20 mg/kg/d of C, Q and CQ improved all these parameters. In 3T3-L1 adipocytes, C and Q attenuated TNFα-induced elevated protein carbonyls, increased pro-inflammatory cytokine expression (MCP-1, resistin), and decreased adiponectin. The protective effects of C and Q on adipose inflammation are in part associated with their capacity to: i) decrease the activation of the mitogen activated kinases (MAPKs) JNK and p38; and ii) prevent the downregulation of PPARγ. In summary, C and Q, and to a larger extent the combination of both, attenuated adipose pro-inflammatory signaling cascades and regulated the balance of molecules that improve (adiponectin) or impair (TNFα, MCP-1, resistin) insulin sensitivity. Together, these findings suggest that dietary Q and C may have potential benefits in mitigating MetS associated adipose inflammation, oxidative stress, and insulin resistance.
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影响因子：
5.3
作者：
Lim SY;Davidson SM;Paramanathan AJ;Smith CC;Yellon DM;Hausenloy DJ
通讯作者：
Hausenloy DJ
影响因子：
7.1
作者：
Chuang, Chia Chi;Martinez, Kristina;McIntosh, Michael K.
通讯作者：
McIntosh, Michael K.
影响因子：
5.8
作者：
Cox, Chad L.;Stanhope, Kimber L.;Havel, Peter J.
通讯作者：
Havel, Peter J.
DOI：
10.1016/j.jnutbio.2013.06.003
发表时间：
2013-11
期刊：
The Journal of nutritional biochemistry
影响因子：
--
作者：
Babu PV;Liu D;Gilbert ER
通讯作者：
Gilbert ER
肿瘤坏死因子-α的脂肪表达--在与肥胖相关的胰岛素抵抗中的直接作用
影响因子：
56.9
作者：
HOTAMISLIGIL, GS;SHARGILL, NS;SPIEGELMAN, BM
通讯作者：
SPIEGELMAN, BM