DynOmics: dynamics of structural proteome and beyond.
DynOmics: dynamics of structural proteome and beyond.
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DOI：
10.1093/nar/gkx385
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发表时间：
2017-07-03
影响因子：
14.9
通讯作者：
Yang LW
中科院分区：
文献类型：
--
作者：
Li H;Chang YY;Lee JY;Bahar I;Yang LW
DynOmics (dynomics.pitt.edu) is a portal developed to leverage rapidly growing structural proteomics data by efficiently and accurately evaluating the dynamics of structurally resolved systems, from individual molecules to large complexes and assemblies, in the context of their physiological environment. At the core of the portal is a newly developed server, ENM 1.0, which permits users to efficiently generate information on the collective dynamics of any structure in PDB format, user-uploaded or database-retrieved. ENM 1.0 integrates two widely used elastic network models (ENMs)—the Gaussian Network Model (GNM) and the Anisotropic Network Model (ANM), extended to take account of molecular environment. It enables users to assess potentially functional sites, signal transduction or allosteric communication mechanisms, and protein–protein and protein–DNA interaction poses, in addition to delivering ensembles of accessible conformers reconstructed at atomic details based on the global modes of motions predicted by the ANM. The ‘environment’ is defined in a flexible manner, from lipid bilayer and crystal contacts, to substrate or ligands bound to a protein, or surrounding subunits in a multimeric structure or assembly. User-friendly interactive features permit users to easily visualize how the environment alter the intrinsic dynamics of the query systems. ENM 1.0 can be accessed at http://enm.pitt.edu/ or http://dyn.life.nthu.edu.tw/oENM/.
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影响因子：
14.9
作者：
Li H;Chang YY;Yang LW;Bahar I
通讯作者：
Bahar I
影响因子：
3.4
作者：
Bahar, Ivet;Cheng, Mary Hongying;Zhang, She
通讯作者：
Zhang, She
影响因子：
2.9
作者：
Krebs, WG;Alexandrov, V;Gerstein, M
通讯作者：
Gerstein, M
影响因子：
14.9
作者：
Frappier V;Chartier M;Najmanovich RJ
通讯作者：
Najmanovich RJ
影响因子：
14.9
作者：
Lindahl E;Azuara C;Koehl P;Delarue M
通讯作者：
Delarue M