FOXO Transcriptional Factors and Long-Term Living.
FOXO Transcriptional Factors and Long-Term Living.
复制标题
FOXO的转录因素和长期生活。
DOI：
10.1155/2017/3494289
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发表时间：
2017
影响因子：
--
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Murtaza G;Khan AK;Rashid R;Muneer S;Hasan SMF;Chen J
一些病理学如神经变性和癌症与衰老有关，衰老受到许多遗传和环境因素的影响。健康的老龄化使人类长寿，可能是由于携带了防御基因。例如，FOXO（forkhead box O）基因决定了人类的寿命。FOXO转录因子通过胰岛素和胰岛素样生长因子信号通路参与长寿现象的调控。无脊椎动物中仅存在一个FOXO基因（FOXO DAF-16），而哺乳动物中存在四个FOXO基因，即FOXO 1、FOXO 3、FOXO 4和FOXO 6。这四种转录因子参与多种细胞途径，调节哺乳动物的生长、抗逆、代谢、细胞分化和凋亡。然而，FOXO因素对寿命的准确影响模式至今仍不清楚。本文简要介绍了现有的知识，有关的作用FOXO因素在人类寿命。
Several pathologies such as neurodegeneration and cancer are associated with aging, which is affected by many genetic and environmental factors. Healthy aging conceives human longevity, possibly due to carrying the defensive genes. For instance, FOXO (forkhead box O) genes determine human longevity. FOXO transcription factors are involved in the regulation of longevity phenomenon via insulin and insulin-like growth factor signaling. Only one FOXO gene (FOXO DAF-16) exists in invertebrates, while four FOXO genes, that is, FOXO1, FOXO3, FOXO4, and FOXO6 are found in mammals. These four transcription factors are involved in the multiple cellular pathways, which regulate growth, stress resistance, metabolism, cellular differentiation, and apoptosis in mammals. However, the accurate mode of longevity by FOXO factors is unclear until now. This article describes briefly the existing knowledge that is related to the role of FOXO factors in human longevity.
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影响因子：
29
作者：
Dong XC;Copps KD;Guo S;Li Y;Kollipara R;DePinho RA;White MF
通讯作者：
White MF
DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
2012-04-01
影响因子：
5.1
作者：
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通讯作者：
Perls, Thomas T.
DOI：
10.1093/bioinformatics/btp101
发表时间：
2009-04-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/j.str.2008.06.013
发表时间：
2008-09-10
期刊：
Structure (London, England : 1993)
影响因子：
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作者：
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通讯作者：
Marmorstein R