Effect of Siraitia grosvenorii polysaccharide on glucose and lipid of diabetic rabbits induced by feeding high fat/high sucrose chow.
Effect of Siraitia grosvenorii polysaccharide on glucose and lipid of diabetic rabbits induced by feeding high fat/high sucrose chow.
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DOI：
10.1155/2007/67435
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发表时间：
2007
影响因子：
--
通讯作者：
Tuo QH
中科院分区：
文献类型：
--
作者：
Lin GP;Jiang T;Hu XB;Qiao XH;Tuo QH
从罗汉果（Siraitia grosvenorii（Swingle））中分离纯化罗汉果多糖（Siraitia grosvenorii polysaccharide，SGP）。本文研究了SGP对高脂高糖饲料喂养的糖尿病家兔的治疗作用。给药4周后测定空腹血糖（FBG）、血浆胰岛素（INS）、血浆总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）。结果显示，SGP治疗4周后可显著降低血浆总胆固醇、甘油三酯和葡萄糖水平，并升高HDL-C水平。SGP 100 mg·kg-1 bw剂量组的抗高血压作用最显著。SGP对糖尿病家兔的血脂水平有明显的恢复作用（P <0.05）。这些数据表明，SGP不仅改善脂质紊乱，而且降低血糖水平。因此，SGP对高脂高糖饲料诱导的高血糖家兔具有明显的降糖作用，其机制可能与改善高血糖家兔的脂代谢，恢复高血糖家兔的血脂水平有关。
The Siraitia grosvenorii polysaccharide (SGP) from the Siraitia grosvenorii (Swingle) was isolated and purified. The therapeutic effects of SGP on diabetic rabbits induced by feeding high fat/high sucrose chow were studied. After administration of SGP for 4 weeks, the fasting blood glucose (FBG), plasma insulin levels (INS), plasma total cholesterol (TC), triglyceride (TG), and HDL-C were assayed. The results showed that administration of SGP can significantly decrease plasma total cholesterol, triglyceride, and glucose levels; and increase HDL-C levels after 4 weeks of treatment. The antihyperglycaemic effect of SGP at dose of 100 mg·kg−1 bw was the most significant in three dosage groups. Furthermore, SGP could restore the blood lipid levels of diabetic rabbits (). These data indicate that SGP not only ameliorates the lipid disorder, but also lowers plasma glucose levels. So SGP have obvious glucose-lowering effect on hyperglycaemic rabbits induced by feeding high fat/high sucrose chow, its mechanism may be related to amelioration of lipid metabolism and restoring the blood lipid levels of hyperglycaemic rabbits.
DOI：
10.1161/01.atv.17.11.2601
发表时间：
1997-11-01
影响因子：
8.7
作者：
Chiba, T;Miura, S;Tomita, T
通讯作者：
Tomita, T
DOI：
10.1080/15604280214274
发表时间：
2002-07
期刊：
International journal of experimental diabetes research
影响因子：
--
作者：
Yin W;Yuan Z;Wang Z;Yang B;Yang Y
通讯作者：
Yang Y
DOI：
10.1152/ajpregu.2000.279.4.r1334
发表时间：
2000-10-01
影响因子：
2.8
作者：
Thresher, JS;Podolin, DA;Pagliassotti, MJ
通讯作者：
Pagliassotti, MJ