Plasma Proteome Database as a resource for proteomics research: 2014 update.
Plasma Proteome Database as a resource for proteomics research: 2014 update.
复制标题
DOI：
10.1093/nar/gkt1251
复制
发表时间：
2014-01
影响因子：
14.9
通讯作者：
Prasad TS
中科院分区：
文献类型：
--
作者：
Nanjappa V;Thomas JK;Marimuthu A;Muthusamy B;Radhakrishnan A;Sharma R;Ahmad Khan A;Balakrishnan L;Sahasrabuddhe NA;Kumar S;Jhaveri BN;Sheth KV;Kumar Khatana R;Shaw PG;Srikanth SM;Mathur PP;Shankar S;Nagaraja D;Christopher R;Mathivanan S;Raju R;Sirdeshmukh R;Chatterjee A;Simpson RJ;Harsha HC;Pandey A;Prasad TS
血浆蛋白质组数据库（PPD; http：//www.plasmaproteomedatabase.org/）最初在2005年被描述为人类蛋白质组组织（HUPO）关于人类血浆蛋白质组计划的试点计划的一部分。从那时起，蛋白质组学技术的改进和通量的增加导致了大量新的血浆蛋白的鉴定。为了跟上数据的增长，我们显着丰富了PPD中的蛋白质组信息。该数据库目前包含在血清/血浆中检测到的10546种蛋白质的信息，其中3784种已在两项或多项研究中报告。该数据库的最新版本还整合了质谱衍生数据，包括用于多反应监测分析的实验验证的蛋白质型肽。其他新特征包括1278种蛋白质的已发表血浆/血清浓度沿着单独类别的血浆来源的细胞外囊泡蛋白。由于血浆蛋白已成为生物标志物领域的主要推动力，我们已经启用了一个基于批处理的查询命名为血浆蛋白质组探索者，这将允许用户筛选蛋白质或肽的列表对已知的血浆蛋白质，以评估其数据集的新奇。我们相信PPD将通过作为人类血浆蛋白的综合参考来促进临床和基础研究，并加速生物标志物的发现和翻译工作。
Plasma Proteome Database (PPD; http://www.plasmaproteomedatabase.org/) was initially described in the year 2005 as a part of Human Proteome Organization’s (HUPO’s) pilot initiative on Human Plasma Proteome Project. Since then, improvements in proteomic technologies and increased throughput have led to identification of a large number of novel plasma proteins. To keep up with this increase in data, we have significantly enriched the proteomic information in PPD. This database currently contains information on 10 546 proteins detected in serum/plasma of which 3784 have been reported in two or more studies. The latest version of the database also incorporates mass spectrometry-derived data including experimentally verified proteotypic peptides used for multiple reaction monitoring assays. Other novel features include published plasma/serum concentrations for 1278 proteins along with a separate category of plasma-derived extracellular vesicle proteins. As plasma proteins have become a major thrust in the field of biomarkers, we have enabled a batch-based query designated Plasma Proteome Explorer, which will permit the users in screening a list of proteins or peptides against known plasma proteins to assess novelty of their data set. We believe that PPD will facilitate both clinical and basic research by serving as a comprehensive reference of plasma proteins in humans and accelerate biomarker discovery and translation efforts.
登录
查看更多内容
影响因子：
158.5
作者：
Cristofanilli, M;Budd, GT;Hayes, DF
通讯作者：
Hayes, DF
影响因子：
12.3
作者：
Kandasamy K;Mohan SS;Raju R;Keerthikumar S;Kumar GS;Venugopal AK;Telikicherla D;Navarro JD;Mathivanan S;Pecquet C;Gollapudi SK;Tattikota SG;Mohan S;Padhukasahasram H;Subbannayya Y;Goel R;Jacob HK;Zhong J;Sekhar R;Nanjappa V;Balakrishnan L;Subbaiah R;Ramachandra YL;Rahiman BA;Prasad TS;Lin JX;Houtman JC;Desiderio S;Renauld JC;Constantinescu SN;Ohara O;Hirano T;Kubo M;Singh S;Khatri P;Draghici S;Bader GD;Sander C;Leonard WJ;Pandey A
通讯作者：
Pandey A
影响因子：
9.9
作者：
Lange, Vinzenz;Picotti, Paola;Domon, Bruno;Aebersold, Ruedi
通讯作者：
Aebersold, Ruedi
DOI：
10.1007/978-1-61779-068-3_23
发表时间：
2011-01-01
期刊：
SERUM/PLASMA PROTEOMICS: METHODS AND PROTOCOLS
影响因子：
--
作者：
Farrah, Terry;Deutsch, Eric W.;Aebersold, Ruedi
通讯作者：
Aebersold, Ruedi
影响因子：
4.4
作者：
Kim, Hyun-Jung;Cho, Eun-Hee;Kim, Chan-Wha
通讯作者：
Kim, Chan-Wha