In-situ biotransformation of nitric oxide by functionalized surfaces of cardiovascular stents.
In-situ biotransformation of nitric oxide by functionalized surfaces of cardiovascular stents.
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心血管支架功能化表面对一氧化氮的原位生物转化
DOI：
10.1016/j.bioactmat.2020.10.030
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发表时间：
2021-05
影响因子：
18.9
通讯作者：
Zhao Q
中科院分区：
文献类型：
--
作者：
Qian M;Liu Q;Wei Y;Guo Z;Zhao Q
Cardiovascular diseases (CVDs) are among the leading causes of mortality and morbidity worldwide. Nitric oxide (NO) is a signalling molecule that plays a vital role in protecting and regulating cardiovascular function and homeostasis. Despite several successful outcomes of exogenous supplementation of NO for cardiovascular disease therapy, a great challenge lies in controlled and long-term delivery due to the short half-life and instability of NO. Recently, increasing attention has been paid to the in situ conversion of endogenous NO donors catalysed by functional surfaces. Based on bioinspired and biomimicking strategies, a series of surface functionalization methods for cardiovascular stents has been successfully developed. By further combining NO catalysis with other biofunctionalities, improved endothelium healing and long-term patency can be anticipated. Nitric oxide (NO) is a signalling molecule that plays a vital role in cardiovascular system. Surface functionalization provides a promising strategy for the in situ generation of NO from endogenous donors. Combining NO catalysis with other surface biofunctionalities could enhance long-term patency of the cardiovascular stents.
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