Effect of Δ9-Tetrahydrocannabinol on frontostriatal resting state functional connectivity and subjective euphoric response in healthy young adults.
Effect of Δ9-Tetrahydrocannabinol on frontostriatal resting state functional connectivity and subjective euphoric response in healthy young adults.
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DOI：
10.1016/j.drugalcdep.2021.108565
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发表时间：
2021-04-01
影响因子：
4.2
通讯作者：
Phan KL
中科院分区：
文献类型：
--
作者：
Crane NA;Phan KL
很少有研究探讨大麻的主要精神活性成分Δ9-四氢大麻酚（THC）如何影响人类的大脑奖励回路。在这项研究中，我们研究了急性剂量的THC是否改变了健康年轻人中纹状体和前额皮质之间的静息状态功能连接，这些年轻人使用大麻有限。参与者接受THC（n=24）或安慰剂（n=22），采用双盲、随机、受试者间设计。参与者在整个访问过程中完成了欣快感和药物喜好的自我报告措施。给药后约120分钟，参与者完成了8分钟的静息状态功能性MRI（rs-fMRI）扫描。我们利用纹状体（双侧壳核、尾状核和NAcc种子）与额叶皮质的基于种子的连接。与接受安慰剂的个体相比，接受THC的个体在右侧NAcc和内侧前额叶皮层（mPFC）区域之间表现出更大的rs-fMRI连通性（p值<0.05，校正）和更高的主观欣快感评分（p= 0.03）。对于THC组，欣快的评分较高与右侧NAc-背侧mPFC（dmPFC）连接性较高相关（p= 0.03），但安慰剂组则不然（p= 0.98）。这是第一个研究检查THC给药后健康年轻非使用者的rs-fMRI连接的研究之一。我们发现，与接受安慰剂的个体相比，接受THC的个体在NAcc和mPFC之间表现出更大的rs-fMRI连接，这些区域与奖励有关。此外，接受THC的个体报告了更高的主观欣快评分，这与NAcc-dmPFC连接呈正相关。总的来说，我们的研究结果表明，THC可能会产生主观和神经奖励反应，有助于大麻的奖励，增强特性。
Few studies have examined how Δ9-Tetrahydrocannabinol (THC), the main psychoactive component of cannabis, impacts brain reward circuitry in humans. In this study, we examined if an acute dose of THC altered resting state functional connectivity between the striatum and prefrontal cortex among healthy young adults with limited cannabis use. Participants received THC (n=24) or placebo (n=22) in a double-blind, randomized, between-subject design. Participants completed self-report measures of euphoria and drug-liking throughout the visit. Approximately 120 minutes after drug administration, participants completed an 8-minute resting state functional MRI (rs-fMRI) scan. We utilized seed-based connectivity of the striatum (bilateral putamen, caudate, and NAcc seeds) to the frontal cortex. Individuals who received THC demonstrated greater rs-fMRI connectivity between the right NAcc and regions of the medial prefrontal cortex (mPFC) (p-values<0.05, corrected) and higher subjective euphoria ratings p=.03) compared to compared to individuals who received placebo. Higher ratings of euphoria were related to greater right NAcc-dorsal mPFC (dmPFC) connectivity for the THC group (p=.03), but not for the placebo group (p=.98). This is one of the first studies to examine rs-fMRI connectivity in healthy young non-users after THC administration. We found individuals receiving THC show greater rs-fMRI connectivity between the NAcc and mPFC, regions implicated in reward, compared to individuals receiving placebo. In addition, individuals receiving THC reported higher subjective euphoria ratings, which were positively associated with NAcc-dmPFC connectivity. Overall, our findings suggest THC may produce subjective and neural reward responses that contribute to the rewarding, reinforcing properties of cannabis.
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