Brain structures associated with executive functions during everyday events in a non-clinical sample.
Brain structures associated with executive functions during everyday events in a non-clinical sample.
复制标题
非临床样本中与日常事件中的执行功能相关的大脑结构。
DOI：
10.1007/s00429-012-0444-z
复制
发表时间：
2013-07
影响因子：
3.1
通讯作者：
Kawashima, Ryuta
中科院分区：
文献类型：
--
作者：
Takeuchi, Hikaru;Taki, Yasuyuki;Sassa, Yuko;Hashizume, Hiroshi;Sekiguchi, Atsushi;Fukushima, Ai;Kawashima, Ryuta
关键词：
执行功能涉及控制过程，例如目标导向的规划、灵活的策略生成、维持集合维护、自我监控和抑制。日常活动中的执行功能 (EFEE) 与实验室环境下测量的执行功能不同；前者可能受到严重损害，而后者则完好无损。由于执行功能障碍导致的非常规日常问题会影响个人的日常生活功能，并且具有很大的临床意义。尽管更好的 EFEE 背后的解剖学基础很重要，但从未在非临床样本中研究过此类基础。我们使用基于体素的形态测定法来测量区域灰质体积 (rGMV) 和区域白质体积 (rWMV)，并使用扩散张量成像来确定分数各向异性值，我们使用执行功能障碍问卷对 303 名正常年轻受试者（168 名男性和 135 名女性）进行了执行不良问卷调查，确定了更好的 EFEE 的解剖相关性。更好的 EFEE 与分布在 Brodmann 区域 (BA) 25、11 和 12 的眶额皮质 (OFC) 中较小的 rGMV 以及邻近 BA 11 的 OFC WM 区域中较大的 rWMV 相关。此外，个体 EFEE 与颞区的 rWMV 呈正相关，主要是下纵束和下额枕束，后者连接 OFC 和后额束。地区。因此，我们的研究结果表明，涉及 OFC 的大脑结构以及其他区域有助于维持非临床受试者的有效 EFEE。
Executive functions involve control processes such as goal-oriented planning, flexible strategy generation, sustaining set maintenance, self-monitoring, and inhibition. Executive functions during everyday events (EFEEs) are distinct from those measured under laboratory settings; the former can be severely impaired while the latter remain intact. Non-routine everyday problems due to executive dysfunctions affect individual functioning in everyday life and are of great clinical interest. Despite the importance of anatomical bases underlying better EFEEs, such bases have never been investigated among non-clinical samples. Using voxel-based morphometry to measure regional gray matter volume (rGMV) and regional white matter volume (rWMV) and diffusion tensor imaging to determine fractional anisotropy values, we identified the anatomical correlates of better EFEEs using the Dysexecutive Questionnaire in 303 normal young subjects (168 men and 135 women). Better EFEEs were associated with a smaller rGMV in the orbitofrontal cortex (OFC) spread across Brodmann areas (BA) 25, 11, and 12 and larger rWMV in the WM area of OFC adjacent to BA 11. Furthermore, individual EFEEs were positively associated with rWMV in the temporal areas, primarily the inferior longitudinal fasciculus and inferior fronto-occipital fasciculus, the latter of which connects OFC and posterior regions. Thus, our findings suggest that brain structures involving OFC, together with other regions, contribute to the maintenance of effective EFEEs among non-clinical subjects.
登录
查看更多内容
影响因子：
--
作者：
Cooney, LM;Kennedy, GJ;Hurme, SB
通讯作者：
Hurme, SB
影响因子：
1.9
作者：
Bodenburg, Sebastian;Dopslaff, Nina
通讯作者：
Dopslaff, Nina
影响因子：
10.6
作者：
Amaral, DG
通讯作者：
Amaral, DG
影响因子：
5.3
作者：
Boyke, Janina;Driemeyer, Joenna;May, Arne
通讯作者：
May, Arne
影响因子：
2.5
作者：
Amieva, H;Phillips, L;Della Sala, S
通讯作者：
Della Sala, S