Time-frequency analysis of transient-evoked otoacoustic emissions in children exposed to carboplatin chemotherapy.
Time-frequency analysis of transient-evoked otoacoustic emissions in children exposed to carboplatin chemotherapy.
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DOI：
10.1159/000343909
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发表时间：
2013
影响因子：
1.6
通讯作者：
Tognola G
中科院分区：
文献类型：
--
作者：
Bhagat S;Bass J;Qaddoumi I;Brennan R;Wilson M;Wu J;Galindo CR;Paglialonga A;Tognola G
本研究的目的是表征和量化在接受卡铂化疗的视网膜母细胞瘤儿童中记录的瞬时诱发耳声发射（teoae）的时频变化。采用小波变换（WT）信号处理技术对TEOAE的窄带频率分量波形进行分析。10名诊断为单侧或双侧视网膜母细胞瘤的儿童（年龄3-72个月）被纳入研究。从70 dB peSPL点击的线性序列中获得teoae。经WT分析，比较卡铂（平均剂量1693 mg/m2）化疗前后窄带频率分量的TEOAE能量、潜伏期和归一化能量。在组基础上，卡铂治疗前后TEOAE能量、潜伏期或归一化能量无显著差异（p>0.05）。样品中10/18耳的归一化能量在个体基础上有所下降。卡铂化疗在治疗期间并未引起TEOAE能量、潜伏期和标准化能量的显著变化。然而，考虑到一些接受卡铂化疗的儿童存在延迟性听力损失的风险，有必要通过teoae测量对听力进行长期监测。
The aims of this study were to characterize and quantify time-frequency changes in transient-evoked otoacoustic emissions (TEOAEs) recorded in children diagnosed with retinoblastoma who were receiving carboplatin chemotherapy. A signal processing technique, the wavelet transform (WT), was used to analyze TEOAE waveforms in narrow-band frequency components. Ten children (aged 3–72 months) diagnosed with unilateral or bilateral retinoblastoma were enrolled in the study. TEOAEs were acquired from the children with linear sequences of 70 dB peSPL clicks. After WT analysis, TEOAE energy, latency, and normalized energy in the narrow-band frequency components were compared before and during carboplatin (average dose 1693 mg/m2) chemotherapy treatment. On a group basis, no significant differences (p>0.05) in pre- and post-carboplatin TEOAE energy, latency, or normalized energy were observed. There were decreases in normalized energy on an individual basis in 10/18 ears in the sample. Exposure to carboplatin chemotherapy did not cause significant changes in TEOAE energy, latency, and normalized energy during treatment. However, long-term monitoring of hearing with measurements of TEOAEs is warranted given the risks of delayed hearing loss in some children receiving carboplatin chemotherapy.
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DOI：
10.1121/1.3056566
发表时间：
2009-02
期刊：
The Journal of the Acoustical Society of America
影响因子：
--
作者：
Goodman SS;Fitzpatrick DF;Ellison JC;Jesteadt W;Keefe DH
通讯作者：
Keefe DH
影响因子：
2.8
作者：
Jedrzejczak, WW;Blinowska, KJ;Konopka, W
通讯作者：
Konopka, W
影响因子：
5.1
作者：
Abramson, DH;Frank, CM;Boyd, NW
通讯作者：
Boyd, NW
影响因子：
3.4
作者：
Allen, GC;Tiu, C;Wax, MK
通讯作者：
Wax, MK
影响因子：
3.2
作者：
Jehanne, Mathilde;Rouic, Livia Lumbroso-Le;Doz, Franicois
通讯作者：
Doz, Franicois