Patients with anxiety disorders rely on bilateral dlPFC activation during verbal working memory.
Patients with anxiety disorders rely on bilateral dlPFC activation during verbal working memory.
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DOI：
10.1093/scan/nsaa146
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发表时间：
2020-12-24
影响因子：
4.2
通讯作者：
Grillon C
中科院分区：
文献类型：
--
作者：
Balderston NL;Flook E;Hsiung A;Liu J;Thongarong A;Stahl S;Makhoul W;Sheline Y;Ernst M;Grillon C
焦虑症的特征之一是认知控制受损，影响工作记忆（WM）。背外侧前额叶皮层（dlPFC）是至关重要的WM，然而，它仍然不清楚如何dlPFC活动与患者的WM损伤。41名健康志愿者和32名焦虑症（一般和/或社交焦虑障碍）患者在安全和不可预测的休克威胁期间完成了斯滕贝格WM范式。在每一次试验中，都呈现了一系列的字母，然后是简短的保留和响应间隔。在低负荷和高负荷试验中，受试者按原始顺序保留序列（分别为5个和8个字母），而在排序试验中，受试者按字母顺序重新排列序列（5个字母）。我们使用双侧解剖学dlPFC面罩在保留期间采样血氧水平依赖性活动。与对照组相比，患者在高负荷试验期间表现出反应时间增加，右侧dlPFC活性增加，威胁期间dlPFC活性降低。这些结果表明，患者和对照组的WM性能可能依赖于不同的模式，患者需要双边dlPFC活动的dlPFC活动。这些结果与焦虑症患者中WM的效率降低一致。这种效率降低可能是由于dlPFC资源在半球之间的分配效率低下或dlPFC的总体能力下降。
One of the hallmarks of anxiety disorders is impaired cognitive control, affecting working memory (WM). The dorsolateral prefrontal cortex (dlPFC) is critical for WM; however, it is still unclear how dlPFC activity relates to WM impairments in patients. Forty-one healthy volunteers and 32 anxiety (general and/or social anxiety disorder) patients completed the Sternberg WM paradigm during safety and unpredictable shock threat. On each trial, a series of letters was presented, followed by brief retention and response intervals. On low- and high-load trials, subjects retained the series (five and eight letters, respectively) in the original order, while on sort trials, subjects rearranged the series (five letters) in alphabetical order. We sampled the blood oxygenation level–dependent activity during retention using a bilateral anatomical dlPFC mask. Compared to controls, patients showed increased reaction time during high-load trials, greater right dlPFC activity and reduced dlPFC activity during threat. These results suggest that WM performance for patients and controls may rely on distinct patterns of dlPFC activity with patients requiring bilateral dlPFC activity. These results are consistent with reduced efficiency of WM in anxiety patients. This reduced efficiency may be due to an inefficient allocation of dlPFC resources across hemispheres or a decreased overall dlPFC capacity.
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DOI：
10.4088/jcp.08m04638blu
发表时间：
2010-08
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
Boggio PS;Rocha M;Oliveira MO;Fecteau S;Cohen RB;Campanhã C;Ferreira-Santos E;Meleiro A;Corchs F;Zaghi S;Pascual-Leone A;Fregni F
通讯作者：
Fregni F
影响因子：
6.8
作者：
Balderston NL;Liu J;Roberson-Nay R;Ernst M;Grillon C
通讯作者：
Grillon C
影响因子：
2.9
作者：
Fales, C. L.;Barch, D. M.;Braver, T. S.
通讯作者：
Braver, T. S.
影响因子：
7.6
作者：
Altamura, Mario;Goldberg, Terry E.;Coppola, Richard
通讯作者：
Coppola, Richard
影响因子：
2.3
作者：
Altamura, Mario;Elvevag, Brita;Goldberg, Terry E.
通讯作者：
Goldberg, Terry E.