The relationship between dlPFC activity during unpredictable threat and CO(2)-induced panic symptoms.
The relationship between dlPFC activity during unpredictable threat and CO(2)-induced panic symptoms.
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DOI：
10.1038/s41398-017-0006-5
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发表时间：
2017-11-30
影响因子：
6.8
通讯作者：
Grillon C
中科院分区：
文献类型：
--
作者：
Balderston NL;Liu J;Roberson-Nay R;Ernst M;Grillon C
惊恐障碍的特征是突然的、反复的、意想不到的强烈恐惧和对下一次攻击可能发生的压倒性焦虑。惊恐障碍患者和有惊恐发作史的健康人对不可预测的威胁表现出高度敏感，这表明惊恐和持续焦虑之间可能存在联系。本研究的目的是确定引起的恐慌症状与恐惧和焦虑的关系程度，以及介导和调节这些情感状态的神经系统的活动。在8分钟的7.5%二氧化碳挑战任务中评估恐慌的心理和生理症状。恐惧和焦虑的心理、生理和神经症状在两个阶段（一个心理生理阶段和一个功能磁共振成像阶段）中被试经历了无威胁(N)、可预测的冲击(P)和不可预测的冲击（U； NPU威胁任务）。我们使用主成分分析来表征恐慌敏感性（PS），发现PS可以显著预测NPU威胁任务中对不可预测线索的背外侧前额叶皮层（dlPFC）活动。当检查该分析的加权贝塔系数时，我们观察到，在二氧化碳挑战期间自我报告的恐惧/焦虑在NPU任务期间负向加载到dlPFC活动。与这一观察结果一致，在不可预测提示期间dlPFC的活动也与NPU会话期间的焦虑负相关。总之，这些结果表明，恐慌症状和焦虑是由同一个前额叶认知控制系统调节的。
Panic disorder is characterized by sudden, repeated, and unexpected attacks of intense fear and overwhelming anxiety about when another attack may strike. Patients with panic disorder and healthy individuals with a history of panic attacks show a hypersensitivity to unpredictable threats, suggesting a possible link between panic and sustained anxiety. The purpose of this study was to determine the degree to which induced symptoms of panic relate to fear and anxiety, as well as activity in the neural systems that mediate and regulate these affective states. Psychological and physiological symptoms of panic were assessed during an 8-min 7.5% CO2 challenge task. Psychological, physiological, and neural symptoms of fear and anxiety were measured during two sessions (one psychophysiology and one functional magnetic resonance imaging where subjects experienced several blocks of no threat (N), predictable shock (P), and unpredictable shock (U; NPU threat task). We used a principle component analysis to characterize panic susceptibility (PS), and found that PS significantly predicted dorsolateral prefrontal cortex (dlPFC) activity to the unpredictable cue during the NPU threat task. When examining the weighted beta coefficients from this analysis, we observed that self-reported fear/anxiety during the CO2 challenge negatively loaded onto dlPFC activity during the NPU task. Consistent with this observation, dlPFC activity during the unpredictable cue was also negatively correlated with anxiety during the NPU sessions. Together, these results suggest that panic symptoms and anxiety are regulated by the same prefrontal cognitive control system.
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DOI：
10.1038/npp.2009.109
发表时间：
2010-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
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Grillon C