HybraPD atlas: Towards precise subcortical nuclei segmentation using multimodality medical images in patients with Parkinson disease.
HybraPD atlas: Towards precise subcortical nuclei segmentation using multimodality medical images in patients with Parkinson disease.
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HybraPD 图集：使用多模态医学图像对帕金森病患者进行精确的皮层下核分割
DOI：
10.1002/hbm.25556
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发表时间：
2021-09
影响因子：
4.8
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Yu B;Li L;Guan X;Xu X;Liu X;Yang Q;Wei H;Zuo C;Zhang Y
人脑图谱对于帕金森病（PD）的研究和外科治疗至关重要。例如，用于PD的深部脑刺激通常需要人脑图谱用于脑结构识别。然而，很少有图谱可以提供PD的疾病特异性皮质下结构，其中大多数基于T1w和T2w图像。在这项工作中，我们构建了一个HybraPD图谱融合定量易感性映射（QSM）和T1w图像从87例PD患者。构建的HybraPD图谱提供了一系列模板，即T1w、GRE幅度、QSM、R2 * 和脑组织概率图。然后，我们用12个双侧皮质下核手动描绘了一个包裹图，这些核与PD病理高度相关，例如苍白球和黑质中的子区域。此外，我们通过将现有的皮质包裹和白色-物质分割与所提出的皮质下核地图相结合来构建全脑包裹地图。考虑到HybraPD图谱的多模态性，分别使用T1w和QSM模板评估每个细胞核的分割精度。结果表明，HybraPD图谱比现有图谱提供更准确的分割。此外，我们分析代谢的差异，在皮质下的核PD患者和健康对照组之间的应用HybraPD图谱计算摄取值的造影剂的正电子发射断层扫描（PET）图像。基于图谱的分析在PET图像上生成准确的疾病相关脑核团分割。新开发的HybraPD图谱可以作为一个有效的模板，研究大脑皮层下区域的病理改变的PD研究。我们构建了一个HybraPD图谱融合定量磁敏感性映射（QSM）和T1w图像从87例PD患者。基于所提出的模板，我们手动描绘了一个parcellation地图与12个双边皮质下核，这是高度相关的PD病理，如苍白球（GP）和黑质（SN）。我们还分析了PD患者和健康对照受试者之间的皮质下核团的代谢差异，通过应用HybraPD图谱计算PET图像上造影剂的摄取值。
Human brain atlases are essential for research and surgical treatment of Parkinson's disease (PD). For example, deep brain stimulation for PD often requires human brain atlases for brain structure identification. However, few atlases can provide disease‐specific subcortical structures for PD, and most of them are based on T1w and T2w images. In this work, we construct a HybraPD atlas using fused quantitative susceptibility mapping (QSM) and T1w images from 87 patients with PD. The constructed HybraPD atlas provides a series of templates, that is, T1w, GRE magnitude, QSM, R2*, and brain tissue probabilistic maps. Then, we manually delineate a parcellation map with 12 bilateral subcortical nuclei, which are highly related to PD pathology, such as sub‐regions in globus pallidus and substantia nigra. Furthermore, we build a whole‐brain parcellation map by combining existing cortical parcellation and white‐matter segmentation with the proposed subcortical nuclei map. Considering the multimodality of the HybraPD atlas, the segmentation accuracy of each nucleus is evaluated using T1w and QSM templates, respectively. The results show that the HybraPD atlas provides more accurate segmentation than existing atlases. Moreover, we analyze the metabolic difference in subcortical nuclei between PD patients and healthy control subjects by applying the HybraPD atlas to calculate uptake values of contrast agents on positron emission tomography (PET) images. The atlas‐based analysis generates accurate disease‐related brain nuclei segmentation on PET images. The newly developed HybraPD atlas could serve as an efficient template to study brain pathological alterations in subcortical regions for PD research. We construct a HybraPD atlas using fused quantitative susceptibility mapping (QSM) and T1w images from 87 patients with PD. Based on the proposed templates, we manually delineate a parcellation map with 12 bilateral subcortical nuclei, which are highly related to PD pathology, such as globus pallidus (GP) and substantia nigra (SN). We also analyze the metabolic difference in subcortical nuclei between PD patients and healthy control subjects by applying the HybraPD atlas to calculate uptake values of contrast agents on PET images.
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影响因子：
158.5
作者：
Follett, Kenneth A.;Weaver, Frances M.;Reda, Domenic J.
通讯作者：
Reda, Domenic J.
DOI：
10.1002/jmri.25671
发表时间：
2017-11
期刊：
Journal of magnetic resonance imaging : JMRI
影响因子：
--
作者：
Hanspach J;Dwyer MG;Bergsland NP;Feng X;Hagemeier J;Bertolino N;Polak P;Reichenbach JR;Zivadinov R;Schweser F
通讯作者：
Schweser F
影响因子：
5.7
作者：
Fonov V;Evans AC;Botteron K;Almli CR;McKinstry RC;Collins DL;Brain Development Cooperative Group
通讯作者：
Brain Development Cooperative Group
影响因子：
3.5
作者：
Bu, L. -L.;Liu, F. -T.;Wang, J.
通讯作者：
Wang, J.
影响因子：
12.7
作者：
Castellani, RJ;Siedlak, SL;Smith, MA
通讯作者：
Smith, MA