Methods for the computation of templates from quantitative magnetic susceptibility maps (QSM): Toward improved atlas- and voxel-based analyses (VBA).
Methods for the computation of templates from quantitative magnetic susceptibility maps (QSM): Toward improved atlas- and voxel-based analyses (VBA).
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DOI：
10.1002/jmri.25671
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Schweser F
中科院分区：
文献类型：
--
作者：
Hanspach J;Dwyer MG;Bergsland NP;Feng X;Hagemeier J;Bertolino N;Polak P;Reichenbach JR;Zivadinov R;Schweser F
开发和评估使用定量磁化率绘图（QSM）为基于磁共振成像和地图集的方法创建模板的方法。我们研究了四种策略的磁化率脑模板的创建，作为传统的模板生成（CONV）的基础上，只有T1加权（T1 W）图像的连续扩展。一种仅使用T1 w图像的方法涉及CONV（U-CONV）的微小改进。一种方法仅使用磁化率图作为模板生成的输入（DIRECT），另外两种方法分别使用磁化率和T1 w图像的线性组合（HYBRID）和直接使用两种图像模式（MULTI）的算法。在一组N=10名健康人类受试者中评价了这些策略，并由三名有经验的评估者进行了半定量评估。模板质量进行了统计学比较，通过价值估计（WE）获得的对数线性布拉德利-特里模型。对于包括敏感性和T1 w对比度的策略，模板的总体质量更好（MULTI：WE=0.62; HYBRID：WE=0.21），但最佳方法取决于感兴趣的解剖区域。虽然仅使用一种模态的方法导致较低的WE，但仅使用T1 w图像时获得的总体WE最低（直接：WE=0.12; U-CONV：WE=0.05）。仅采用磁化率对比或同时采用磁化率和T1 w对比的模板生成策略可生成最高质量的模板。最佳方法取决于感兴趣的解剖结构。与研究的所有其他方法相比，仅使用T1 w图像（CONV）的既定方法导致图像质量降低。
To develop and assess a method for the creation of templates for VBA and atlas-based approaches using quantitative magnetic susceptibility mapping (QSM). We studied four strategies for the creation of magnetic susceptibility brain templates, derived as successive extensions of the conventional template generation (CONV) based on only T1-weighted (T1w) images. One method that used only T1w images involved a minor improvement of CONV (U-CONV). One method used only magnetic susceptibility maps as input for template generation (DIRECT), and the other two used a linear combination of susceptibility and T1w images (HYBRID) and an algorithm that directly used both image modalities (MULTI), respectively. The strategies were evaluated in a group of N=10 healthy human subjects and semi-quantitatively assessed by three experienced raters. Template quality was compared statistically via worth estimates (WEs) obtained with a log-linear Bradley-Terry model. The overall quality of the templates was better for strategies including both susceptibility and T1w contrast (MULTI: WE=0.62; HYBRID: WE=0.21), but the best method depended on the anatomical region of interest. While methods using only one modality resulted in lower WEs, lowest overall WEs were obtained when only T1w images were used (DIRECT: WE=0.12; U-CONV: WE=0.05). Template generation strategies that employ only magnetic susceptibility contrast or both magnetic susceptibility and T1w contrast produce templates with the highest quality. The optimal approach depends on the anatomical structures of interest. The established approach of using only T1w images (CONV) results in reduced image quality compared to all other approaches studied.
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影响因子：
4.4
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