Caloric restriction and chronic inflammatory diseases.
Caloric restriction and chronic inflammatory diseases.
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DOI：
10.1111/j.1601-0825.2011.01830.x
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发表时间：
2012-01
期刊：
影响因子：
3.8
通讯作者：
Novak MJ
中科院分区：
文献类型：
--
作者：
González O;Tobia C;Ebersole J;Novak MJ
减少卡路里摄入量（卡路里限制）似乎可以持续降低各种生物体的生物衰老率，并防止与年龄相关的疾病，包括慢性炎症性疾病，如心血管疾病和糖尿病。虽然这一观察结果背后的机制尚未完全理解，但对受热量限制影响的主要代谢途径的鉴定已经引起了人们对寻找可由热量限制模拟物调节的分子靶点的兴趣。本文综述了热量限制和热量限制模拟物的一般概念，并讨论了它们对炎症和慢性炎症性疾病影响的证据。此外，新出现的证据有关的影响热量限制牙周病在非人类灵长类动物。虽然这种类型的饮食干预的实施似乎是具有挑战性的，在我们的现代社会中，肥胖是一个主要的公共卫生问题，热量限制模拟物可以提供一个有前途的替代控制，也许可以预防几种慢性炎症性疾病，包括牙周病。
A reduction in calorie intake (Caloric restriction), appears to consistently decrease the biological rate of aging in a variety of organisms as well as protect against age-associated diseases including chronic inflammatory disorders such as cardiovascular disease and diabetes. Although the mechanisms behind this observation are not fully understood, identification of the main metabolic pathways affected by caloric restriction has generated interest in finding molecular targets that could be modulated by caloric restriction mimetics. This review describes the general concepts of caloric restriction and caloric restriction mimetics as well as discusses evidence related to their effects on inflammation and chronic inflammatory disorders. Additionally, emerging evidence related to the effects of caloric restriction on periodontal disease in non-human primates is presented. While the implementation of this type of dietary intervention appears to be challenging in our modern society where obesity is a major public health problem, caloric restriction mimetics could offer a promising alternative to control and perhaps prevent several chronic inflammatory disorders including periodontal disease.
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DOI：
10.1084/jem.20081297
发表时间：
2008-09-29
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chen C;Liu Y;Liu R;Ikenoue T;Guan KL;Liu Y;Zheng P
通讯作者：
Zheng P
影响因子：
4.2
作者：
Barzilai, N;Gabriely, I
通讯作者：
Gabriely, I
DOI：
10.1016/j.tem.2009.11.005
发表时间：
2010-03
期刊：
Trends in endocrinology and metabolism: TEM
影响因子：
--
作者：
Anderson RM;Weindruch R
通讯作者：
Weindruch R
影响因子：
29
作者：
Bjedov I;Toivonen JM;Kerr F;Slack C;Jacobson J;Foley A;Partridge L
通讯作者：
Partridge L
影响因子：
7.2
作者：
Andreelli, F.;Amouyal, C.;Mithieux, G.
通讯作者：
Mithieux, G.