Omega-3 fatty acids, homocysteine, and the increased risk of cardiovascular mortality in major depressive disorder.

Omega-3 fatty acids, homocysteine, and the increased risk of cardiovascular mortality in major depressive disorder.
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Omega-3 脂肪酸、同型半胱氨酸和重度抑郁症心血管死亡风险增加。

DOI:
10.1080/10673220127910
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发表时间:
2001
影响因子:
3.8
通讯作者:
Stoll,AL
Stoll,AL
中科院分区:
医学3区
文献类型:
--
作者:
Severus,WE;Littman,AB;Stoll,AL

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抑郁症与心血管疾病发病率和死亡率升高有关。这种升高似乎是由于冠状动脉疾病和心肌梗死的风险显著增加,一旦缺血性心脏病确立,心脏性猝死。最近的数据表明,抑郁症患者心血管疾病的发病率增加可能是一个或多个尚未认识到的潜在生理因素的结果,这些因素使患者易患抑郁症和心血管疾病。两个可能与抑郁症和心血管疾病都有因果关系的相关因素是ω-3脂肪酸缺乏和同型半胱氨酸水平升高。我们提出了现有的数据连接心血管疾病,抑郁症,ω-3脂肪酸和同型半胱氨酸。此外,我们提出了研究策略和一些初步的治疗建议,可能会降低重度抑郁症患者心血管死亡率的风险增加。
Depression is associated with elevated rates of cardiovascular morbidity and mortality. This elevation seems to be due to a significantly increased risk of coronary artery disease and myocardial infarction and, once the ischemic heart disease is established, sudden cardiac death. Recent data suggest that the increased rates of cardiovascular disease in patients with depression may be the result of one or more still-unrecognized underlying physiological factors that predispose a patient to both depression and cardiovascular disease. Two possibly related factors that may have a causal relation with both depressive disorders and cardiovascular disease are an omega-3 fatty acid deficiency and elevated homocysteine levels. We present the available data connecting cardiovascular disease, depression, omega-3 fatty acids, and homocysteine. In addition, we suggest research strategies and some preliminary treatment recommendations that may reduce the increased risk of cardiovascular mortality in patients with major depressive disorder.
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