The receptor kinase SRF3 coordinates iron-level and flagellin dependent defense and growth responses in plants.

The receptor kinase SRF3 coordinates iron-level and flagellin dependent defense and growth responses in plants.
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DOI:
10.1038/s41467-022-32167-6
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发表时间:
2022-08-01
影响因子:
16.6
通讯作者:
--
中科院分区:
综合性期刊1区
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--
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铁对宿主-病原体相互作用至关重要。虽然病原体寻求铁来传播,但宿主的目的是减少铁的可用性以降低病原体的毒力。因此,铁感应和体内平衡对于防止宿主感染和营养免疫的一部分特别重要。虽然铁稳态和免疫途径之间的联系在植物中已经建立,但铁水平如何被感知并与免疫反应途径整合仍然未知。在这里,我们报告了一个受体激酶SRF 3,具有协调根生长,铁稳态和免疫途径通过调节胼胝质分解酶的作用。这些过程由铁水平调节,并依赖于SRF 3细胞外和激酶结构域,调节其在细胞表面的积累和分配。用鞭毛蛋白肽flg 22模拟细菌诱导,模拟SRF 3对低铁水平的调节和随后的SRF 3依赖性反应。我们认为SRF 3是参与感知外部铁水平的营养免疫反应的一部分。已知铁稳态影响植物免疫信号传导。在这里,作者描述了SRF 3,一种受体激酶,作为胼胝质合成的负调控因子,这是根对缺铁和病原体信号的反应所必需的。
Iron is critical for host–pathogen interactions. While pathogens seek to scavenge iron to spread, the host aims at decreasing iron availability to reduce pathogen virulence. Thus, iron sensing and homeostasis are of particular importance to prevent host infection and part of nutritional immunity. While the link between iron homeostasis and immunity pathways is well established in plants, how iron levels are sensed and integrated with immune response pathways remains unknown. Here we report a receptor kinase SRF3, with a role in coordinating root growth, iron homeostasis and immunity pathways via regulation of callose synthases. These processes are modulated by iron levels and rely on SRF3 extracellular and kinase domains which tune its accumulation and partitioning at the cell surface. Mimicking bacterial elicitation with the flagellin peptide flg22 phenocopies SRF3 regulation upon low iron levels and subsequent SRF3-dependent responses. We propose that SRF3 is part of nutritional immunity responses involved in sensing external iron levels. Iron homeostasis is known to influence plant immune signaling. Here the authors characterize SRF3, a receptor kinase that acts as a negative regulator of callose synthesis, that is required for root responses to iron deficiency and pathogen signals.
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