Actomyosin pulsation and flows in an active elastomer with turnover and network remodeling.
Actomyosin pulsation and flows in an active elastomer with turnover and network remodeling.
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肌动球蛋白的脉动并在活性弹性体中流动，并具有离职率和网络重塑。
DOI：
10.1038/s41467-017-01130-1
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发表时间：
2017-10-24
影响因子：
16.6
通讯作者：
Rao M
中科院分区：
文献类型：
--
作者：
Banerjee DS;Munjal A;Lecuit T;Rao M
组织重塑需要与肌动球蛋白细胞骨架的脉动和流动相关的细胞形状改变。在这里，我们将肌动球蛋白的流体动力学描述为具有其成分周转的受限活性弹性体。我们的处理适应于描述在体内观察到的收缩动力机制的多样性。当肌球蛋白诱导的收缩应力较低时，活性弹性体的变形是仿射的，表现为自发振荡、传播波、收缩坍缩和时空混沌。我们研究了肌动球蛋白密集区域的成核，生长和合并，超过一个阈值，自发地作为一个空间局部的旅行前沿移动。大肌球蛋白诱导的收缩应力导致非仿射变形，由于增强肌动蛋白和交联剂的周转。这导致瞬时肌动蛋白网络不断重塑，并自然地适应肌动球蛋白密集区域的网络内流动。我们验证了我们在果蝇胚胎上皮细胞在种带扩展过程中进行邻居交换的许多预测。组织重塑涉及收缩肌动球蛋白细胞骨架的实质性参与。在这里，作者模拟了果蝇胚带扩展过程中肌动球蛋白密度的时空演变，发现仿射和非仿射变形依赖于局部收缩应力的大小。
Tissue remodeling requires cell shape changes associated with pulsation and flow of the actomyosin cytoskeleton. Here we describe the hydrodynamics of actomyosin as a confined active elastomer with turnover of its components. Our treatment is adapted to describe the diversity of contractile dynamical regimes observed in vivo. When myosin-induced contractile stresses are low, the deformations of the active elastomer are affine and exhibit spontaneous oscillations, propagating waves, contractile collapse and spatiotemporal chaos. We study the nucleation, growth and coalescence of actomyosin-dense regions that, beyond a threshold, spontaneously move as a spatially localized traveling front. Large myosin-induced contractile stresses lead to nonaffine deformations due to enhanced actin and crosslinker turnover. This results in a transient actin network that is constantly remodeling and naturally accommodates intranetwork flows of the actomyosin-dense regions. We verify many predictions of our study in Drosophila embryonic epithelial cells undergoing neighbor exchange during germband extension. Tissue remodeling involves substantial involvement of the contractile actomyosin cytoskeleton. Here the authors model the spatiotemporal evolution of actomyosin densities during Drosophila germband extension and find affine and nonaffine deformations that depend on the magnitude of local contractile stress.
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影响因子：
64.8
作者：
Martin, Adam C.;Kaschube, Matthias;Wieschaus, Eric F.
通讯作者：
Wieschaus, Eric F.
影响因子：
64.8
作者：
Cavey, Matthieu;Rauzi, Matteo;Lecuit, Thomas
通讯作者：
Lecuit, Thomas
影响因子：
8.6
作者：
Dierkes, Kai;Sumi, Angughali;Salbreux, Guillaume
通讯作者：
Salbreux, Guillaume
影响因子：
64.8
作者：
Mayer, Mirjam;Depken, Martin;Grill, Stephan W.
通讯作者：
Grill, Stephan W.
DOI：
10.1073/pnas.1418732112
发表时间：
2015-02-03
影响因子：
11.1
作者：
Bambardekar, Kapil;Clement, Raphael;Lenne, Pierre-Francois
通讯作者：
Lenne, Pierre-Francois