Assessment of Binge-Like Eating of Unsweetened vs. Sweetened Chow Pellets in BALB/c Substrains.
Assessment of Binge-Like Eating of Unsweetened vs. Sweetened Chow Pellets in BALB/c Substrains.
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DOI：
10.3389/fnbeh.2022.944890
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发表时间：
2022
影响因子：
3
通讯作者：
中科院分区：
文献类型：
--
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暴食症（BED）是指在不到2小时内消耗大量食物的慢性发作。暴饮暴食是一个严重的公共卫生问题，因为它会增加肥胖、II型糖尿病和心脏病的风险。暴饮暴食是一种高度遗传的特征;然而，它的遗传基础在很大程度上仍未被探索。我们采用了一种暴食小鼠模型，重点是在有限的、间歇性的接触范式中，识别急性和逐步增加摄入蔗糖甜味可口食物与不加糖的食物颗粒的近交系亚系之间的遗传差异。在本研究中，我们研究了两个遗传相似的BALB/c小鼠亚系的食物消耗量的升级，无食物训练期后的渴望孵化，以及在令人厌恶的背景下的强迫性食物消耗。BALB/cJ和BALB/cByJ小鼠在训练试验中表现出相当水平的急性和逐步增加的可口食物消耗。令人惊讶的是，BALB/cByJ小鼠也显示出类似于两种亚系的可口食物摄入量的增加的无糖食物颗粒的暴食样进食。最后，我们在BALB/cByJ小鼠中复制了在光-暗冲突测试中焦虑样行为的充分记录的减少，这可能有助于在光竞技场中比BALB/cJ更大的可口食物摄入。总之，BALB/cByJ小鼠在存在和不存在蔗糖的情况下显示暴食样进食。可能的解释是，在不同的饮食中，暴饮暴食缺乏选择性（例如，新奇，口味）。
Binge eating disorder (BED) is defined as chronic episodes of consuming large amounts of food in less than 2 h. Binge eating disorder poses a serious public health problem, as it increases the risk of obesity, type II diabetes, and heart disease. Binge eating is a highly heritable trait; however, its genetic basis remains largely unexplored. We employed a mouse model for binge eating that focused on identifying heritable differences between inbred substrains in acute and escalated intake of sucrose-sweetened palatable food vs. unsweetened chow pellets in a limited, intermittent access paradigm. In the present study, we examined two genetically similar substrains of BALB/c mice for escalation in food consumption, incubation of craving after a no-food training period, and compulsive-like food consumption in an aversive context. BALB/cJ and BALB/cByJ mice showed comparable levels of acute and escalated consumption of palatable food across training trials. Surprisingly, BALB/cByJ mice also showed binge-like eating of the unsweetened chow pellets similar to the escalation in palatable food intake of both substrains. Finally, we replicated the well-documented decrease in anxiety-like behavior in BALB/cByJ mice in the light-dark conflict test that likely contributed to greater palatable food intake than BALB/cJ in the light arena. To summarize, BALB/cByJ mice show binge-like eating in the presence and absence of sucrose. Possible explanations for the lack of selectivity in binge-like eating across diets (e.g., novelty preference, taste) are discussed.
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影响因子：
7.3
作者：
Grucza, Richard A.;Przybeck, Thomas R.;Cloninger, C. Robert
通讯作者：
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影响因子：
5.5
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影响因子：
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通讯作者：
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影响因子：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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