Integrative Review of Early Life Adversity and Cortisol Regulation in Pregnancy.
Integrative Review of Early Life Adversity and Cortisol Regulation in Pregnancy.
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DOI：
10.1016/j.jogn.2020.12.006
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Weiss SJ
中科院分区：
文献类型：
--
作者：
Epstein CM;Houfek JF;Rice MJ;Weiss SJ
综合已发表的有关孕妇早期生活逆境与下丘脑-垂体-肾上腺轴（HPA）皮质醇参数关系的研究结果。我们搜索PubMed， CINAHL和PsychINFO数据库，使用关键词早期生活逆境，怀孕，下丘脑-垂体-肾上腺轴和皮质醇的变体和组合。我们选择的文章包括怀孕的参与者，包括皮质醇和早期生活逆境的测量，用英文发表在同行评审的期刊上，并且具有足够的方法学质量。发布日期到2020年5月不受限制。25篇文章符合纳入标准，并对其质量和偏倚风险进行了评估。皮质醇的来源包括唾液、毛发、血浆和羊水。我们根据四个生理上不同的皮质醇输出参数对结果进行了分类：日（每日模式）、相位（对急性应激源的反应）、强直（基线水平）和妊娠相关变化。初步证据表明，早期逆境可能与皮质醇觉醒反应升高（昼夜）和对急性压力源的迟钝反应（阶段性）有关，而与其他社会心理症状或当前压力无关。对于目前有高水平压力或心理症状的女性，早期的逆境与较高的基线（强直）皮质醇水平有关。女性早期生活中的逆境与皮质醇调节的改变有关，这种改变在怀孕期间很明显。研究人员应该研究每个皮质醇参数的变化如何差异地预测妊娠健康风险行为、孕产妇心理健康和新生儿健康结果。妇女早期生活的逆境与生理皮质醇的改变有关，这在怀孕期间是明显的。
To synthesize published findings on the relationship between early life adversity and hypothalamic-pituitary-adrenal axis (HPA) cortisol parameters in pregnant women. We searched PubMed, CINAHL, and PsychINFO databases using variants and combinations of the keywords early life adversity, pregnancy, hypothalamic-pituitary-adrenal axis, and cortisol. We selected articles that included pregnant participants, included measures of both cortisol and early life adversity, were published in English in a peer-reviewed journal, and were of sufficient methodological quality. Date of publication was unrestricted through May 2020. Twenty-five articles met the inclusion criteria and were evaluated for quality and risk of bias. Sources of cortisol included saliva, hair, plasma, and amniotic fluid. We categorized findings according to four physiologically distinct cortisol output parameters: diurnal (daily pattern), phasic (in response to an acute stressor), tonic (baseline level) and pregnancy-related change. Preliminary evidence suggests that early adversity may be associated with elevated cortisol awakening response (diurnal) and blunted response to acute stressors (phasic), irrespective of other psychosocial symptoms or current stress. For women with high levels of current stress or psychological symptoms, early adversity was associated with higher baseline (tonic) cortisol levels. Early life adversity in women is linked with alterations in cortisol regulation that are apparent during pregnancy. Researchers should examine how variations in each cortisol parameter differentially predict pregnancy health risk behaviors, maternal mental health, and neonatal health outcomes. Early life adversity in women was associated with physiologic cortisol alterations that are evident during pregnancy.
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昼夜皮质醇斜率以及心理和身体健康结果：系统评价和荟萃分析。
影响因子：
3.7
作者：
Adam EK;Quinn ME;Tavernier R;McQuillan MT;Dahlke KA;Gilbert KE
通讯作者：
Gilbert KE
DOI：
10.1111/infa.12176
发表时间：
2017-07
期刊：
Infancy : the official journal of the International Society on Infant Studies
影响因子：
--
作者：
Enlow MB;Devick KL;Brunst KJ;Lipton LR;Coull BA;Wright RJ
通讯作者：
Wright RJ
影响因子：
3.7
作者：
Enlow, Michelle Bosquet;Sideridis, Georgios;Wright, Rosalind J.
通讯作者：
Wright, Rosalind J.
影响因子：
8
作者：
Dube, SR;Felitti, VJ;Anda, RF
通讯作者：
Anda, RF
影响因子：
0.7
作者：
Bublitz, Margaret H.;Bourjeily, Ghada;Stroud, Laura R.
通讯作者：
Stroud, Laura R.