Preserved cortical somatotopic and motor representations in tetraplegic humans.
Preserved cortical somatotopic and motor representations in tetraplegic humans.
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DOI：
10.1016/j.conb.2022.102547
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发表时间：
2022-06
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
丰富的文献已经记录了躯体感觉和运动皮层中的身体皮层表征的变化。最近的临床研究，旨在帮助瘫痪患者的脑机接口提供了机会，记录和刺激从人类的躯体感觉，运动，和动作相关领域的后顶叶皮层。这些研究表明，在皮层躯体运动系统中有相当多的保留结构。运动皮层可以立即控制辅助设备，体感皮层的刺激在有序的躯体位置图中产生感觉，后顶叶皮层显示认知动作变量的高维表示。这些结果与健康受试者的预期惊人相似，表明即使在严重受伤后，成人皮质也具有相当大的稳定性，尽管皮质同一区域内可能存在可塑性诱导的新激活。临床上，这些结果强调了针对BMI控制信号的皮质区域的重要性，这些信号与其正常功能作用一致。
A rich literature has documented changes in cortical representations of the body in somatosensory and motor cortex. Recent clinical studies of brain-machine interfaces designed to assist paralyzed patients have afforded the opportunity to record and stimulate from human somatosensory, motor, and action-related areas of the posterior parietal cortex. These studies show considerable preserved structure in the cortical somato-motor system. Motor cortex can immediately control assistive devices, stimulation of somatosensory cortex produces sensations in an orderly somatotopic map, and the posterior parietal cortex shows a high-dimensional representation of cognitive action variables. These results are strikingly similar to what would be expected in a healthy subject, demonstrating considerable stability of adult cortex even after severe injury and despite potential plasticity-induced new activations within the same region of cortex. Clinically, these results emphasize the importance of targeting cortical areas for BMI control signals that are consistent with their normal functional role.
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DOI：
10.1093/brain/awx270
发表时间：
2017-11-01
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Catani M
通讯作者：
Catani M
影响因子：
9.8
作者：
Ganguly K;Carmena JM
通讯作者：
Carmena JM
影响因子：
7.7
作者：
Chivukula S;Zhang CY;Aflalo T;Jafari M;Pejsa K;Pouratian N;Andersen RA
通讯作者：
Andersen RA
影响因子：
2.5
作者：
FETZ, EE;BAKER, MA
通讯作者：
BAKER, MA
影响因子：
11.2
作者：
Byblow, Winston D.;Stinear, Cathy M.;Ackerley, Suzanne J.
通讯作者：
Ackerley, Suzanne J.