Phytopathogen type III effector weaponry and their plant targets.
Phytopathogen type III effector weaponry and their plant targets.
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DOI：
10.1016/j.pbi.2008.06.007
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发表时间：
2008-08
影响因子：
9.5
通讯作者：
Alfano, James R.
中科院分区：
文献类型：
--
作者：
Block, Anna;Li, Guangyong;Fu, Zheng Qing;Alfano, James R.
植物病原细菌通过使用III型蛋白质分泌系统将称为III型效应子的蛋白质注射到植物细胞中来抑制植物先天免疫并促进致病性。这些III型效应器使用至少三种主要策略来改变宿主反应。一种策略是通过直接切割或通过调节泛素化和靶向26 S蛋白酶体来改变宿主蛋白质周转。另一种策略涉及通过RNA结合蛋白的转录激活或ADP-核糖基化来改变RNA代谢。第三个主要策略是通过去除磷酸盐或直接抑制来抑制参与植物防御信号传导的激酶。病原细菌抑制植物天然免疫的多种策略表明，规避天然免疫是病原细菌致病性的关键。
Phytopathogenic bacteria suppress plant innate immunity and promote pathogenesis by injecting proteins called type III effectors into plant cells using a type III protein secretion system. These type III effectors use at least three major strategies to alter host responses. One strategy is to alter host protein turnover, either by direct cleavage or by modulating ubiquitination and targeting to the 26S proteasome. Another strategy involves alteration of RNA metabolism by transcriptional activation or ADP-ribosylation of RNA-binding proteins. A third major strategy is to inhibit the kinases involved in plant defence signalling, either by removing phosphates or by direct inhibition. The wide array of strategies bacterial pathogens employ to suppress innate immunity suggest that circumvention of innate immunity is critical for bacterial pathogenicity of plants.
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DOI：
10.1073/pnas.0704901104
发表时间：
2007-12-11
影响因子：
11.1
作者：
Chen, Zhongying;Agnew, Jennifer L.;Kunkel, Barbara N.
通讯作者：
Kunkel, Barbara N.
影响因子：
11.4
作者：
de Torres-Zabala, Marta;Truman, William;Grant, Murray
通讯作者：
Grant, Murray
影响因子：
64.8
作者：
Gu, KY;Yang, B;Yin, ZC
通讯作者：
Yin, ZC
DOI：
10.1073/pnas.0509393103
发表时间：
2006-09-26
影响因子：
11.1
作者：
Angot, Aurelie;Peeters, Nemo;Genin, Stephane
通讯作者：
Genin, Stephane
影响因子：
64.5
作者：
Axtell, MJ;Staskawicz, BJ
通讯作者：
Staskawicz, BJ