Differential expression of SHP2, a protein-tyrosine phosphatase with SRC homology-2 domains, in various types of renal tumour-猫眼课题宝

SHP2（一种具有SRC同源2结构域的蛋白酪氨酸磷酸酶）在不同类型肾肿瘤中的差异表达

DOI：

发表时间：

1998

期刊：

Virchows Archiv

影响因子：

3.5

通讯作者：

中科院分区：

医学3区

文献类型：

作者：

N. Kuroda;Yoshitake Hayashi;T. Matozaki;K. Hanioka;A. Gotoh;Weiping Wang;H. Uchida;K. Hashimoto;Y. Iwai;K. Kawasaki;Y. Imai;M. Kasuga;H. Itoh

摘要SHP 2是一种广泛分布的蛋白酪氨酸磷酸酶，具有src同源性2（SH 2）结构域，在脑中高度表达，可能在突触通讯或细胞增殖中发挥作用。在这项研究中，我们研究了SHP 2蛋白表达在110肾细胞肿瘤的各种组织学亚型，包括透明，颗粒状，乳头状，嫌色细胞，集合管，肉瘤样型肾细胞癌（RCC），和嗜酸细胞瘤。SHP 2主要表达于正常远端小管和集合管，在各种类型的肾肿瘤中的阳性率如下：透明细胞RCC，0%，结节性癌7.7%（1/13），乳头状癌50%（3/6），肉瘤样癌0%（0/1），嫌色细胞癌85.7%（6/7），集合管癌0%（0/2）。嗜酸细胞瘤100%（4/4）。透明型和颗粒型RCC中SHP 2表达极低，但呈阳性。SHP 2蛋白在肾嫌色细胞癌和嗜酸细胞瘤中的表达率最高，表达强度最强。SHP 2可以作为检测罕见肿瘤的有力标志物。其表达的估计可能是有用的组织学诊断。

Abstract SHP2, a widely distributed protein-tyrosine phosphatase with src homology-2 (SH2) domains, is highly expressed in the brain and may play a role in synaptic communications or cellular proliferation. In this study, we examined SHP2 protein expression in 110 renal cell tumours of various histological subtypes, including clear, granular, papillary, chromophobe, collecting duct, and sarcomatoid-type renal cell carcinoma (RCC), and oncocytoma. SHP2 was expressed predominantly in normal distal tubules and collecting ducts, and positivity in various types of renal tumours was as follows: clear cell RCC, 0% (0/77 cases); granular, 7.7% (1/13); papillary, 50% (3/6); sarcomatoid, 0% (0/1); chromophobe, 85.7% (6/7); collecting duct carcinoma, 0% (0/2); oncocytoma, 100% (4/4). Clear and granular-type RCCs showed a very low but positive expression of SHP2. Chromophobe RCC and oncocytoma showed the highest rates and strongest intensities of SHP2 protein on immunostaining. SHP2 may serve as a powerful marker in detecting rare tumours. Estimates of its expression may be useful in histological diagnosis.