Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord.

Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord.
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DOI:
10.1155/2013/916136
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发表时间:
2013
影响因子:
--
通讯作者:
Roberts S
Roberts S
中科院分区:
生物学3区
文献类型:
--
作者:
Mennan C;Wright K;Bhattacharjee A;Balain B;Richardson J;Roberts S

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脐带作为干细胞的来源对于细胞疗法越来越感兴趣,因为它们几乎没有伦理考虑,并且据报道含有可能适合于基于同种异体的疗法的免疫特权细胞。文献中描述了来源于几个不同脐带区域的间充质干细胞(MSC),包括动脉、静脉、脐带衬里和沃顿氏胶。然而,还没有一项研究从同一脊髓的所有区域分离和表征MSC,以确定最适合用于基于细胞的治疗的细胞。
Umbilical cords as a source of stem cells are of increasing interest for cell therapies as they present little ethical consideration and are reported to contain immune privileged cells which may be suitable for allogeneic based therapies. Mesenchymal stem cells (MSCs) sourced from several different cord regions, including artery, vein, cord lining, and Wharton's jelly, are described in the literature. However, no one study has yet isolated and characterised MSCs from all regions of the same cord to determine the most suitable cells for cell based therapeutics.
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