Pseudomonas biofilm matrix composition and niche biology.
Pseudomonas biofilm matrix composition and niche biology.
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DOI：
10.1111/j.1574-6976.2011.00322.x
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发表时间：
2012-07
影响因子：
11.3
通讯作者：
Wozniak DJ
中科院分区：
文献类型：
--
作者：
Mann EE;Wozniak DJ
生物膜是细菌在环境和临床中的主要生长形式。生物膜形成的关键是附着、增殖和分散阶段。这些阶段中的每一个都包括细胞外基质的强化或调节。铜绿假单胞菌是研究生物膜形成的模式生物。此外，其他假单胞菌在植物定居和环境持久性期间利用生物膜的形成。假单胞菌产生几种生物膜基质分子，包括多糖、核酸和蛋白质。假单胞菌也产生辅助基质成分，有助于生物膜的形成和在不同条件下的适应性。通过生物膜的形成促进适应，允许选择具有独特和可区分的菌落形态的遗传变异。例子包括皱纹小菌落变种和皱纹散布器(WS)，它们分别过度产生PSL/PEL或纤维素，以及过度产生海藻酸盐的黏液细菌。这些变异的出现得到了很好的证明，这表明假单胞菌利用矩阵构建亚群的优势，为整个人群带来特定的好处。本文将重点介绍各种多糖以及假单胞菌生物膜基质成分的研究进展。讨论将集中在结构-功能关系、调节以及单个基质分子在生态位生物学中的作用。
Biofilms are a predominant form of growth for bacteria in the environment and in the clinic. Critical for biofilm development are adherence, proliferation, and dispersion phases. Each of these stages includes reinforcement by, or modulation of, the extracellular matrix. Pseudomonas aeruginosa has been a model organism for the study of biofilm formation. Additionally, other Pseudomonas species utilize biofilm formation during plant colonization and environmental persistence. Pseudomonads produce several biofilm matrix molecules, including polysaccharides, nucleic acids, and proteins. Accessory matrix components shown to aid biofilm formation and adaptability under varying conditions are also produced by pseudomonads. Adaptation facilitated by biofilm formation allows for selection of genetic variants with unique and distinguishable colony morphology. Examples include rugose small-colony variants and wrinkly spreaders (WS), which over produce Psl/Pel or cellulose, respectively, and mucoid bacteria that over produce alginate. The well-documented emergence of these variants suggests that pseudomonads take advantage of matrix-building subpopulations conferring specific benefits for the entire population. This review will focus on various polysaccharides as well as additional Pseudomonas biofilm matrix components. Discussions will center on structure–function relationships, regulation, and the role of individual matrix molecules in niche biology.
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影响因子：
3.6
作者：
Boles, BR;Thoendel, M;Singh, PK
通讯作者：
Singh, PK
影响因子：
6.4
作者：
Byrd, Matthew S.;Pang, Bing;Wozniak, Daniel J.
通讯作者：
Wozniak, Daniel J.
影响因子：
5.1
作者：
Barken, Kim B.;Pamp, Suenje J.;Tolker-Nielsen, Tim
通讯作者：
Tolker-Nielsen, Tim
DOI：
10.1073/pnas.1731982100
发表时间：
2003-09-02
影响因子：
11.1
作者：
Buell, CR;Joardar, V;Collmer, A
通讯作者：
Collmer, A
影响因子：
3.6
作者：
Allesen-Holm, M;Barken, KB;Tolker-Nielsen, T
通讯作者：
Tolker-Nielsen, T