Cerebellar Modules and Their Role as Operational Cerebellar Processing Units: A Consensus paper [corrected].
Cerebellar Modules and Their Role as Operational Cerebellar Processing Units: A Consensus paper [corrected].
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DOI：
10.1007/s12311-018-0952-3
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Ruigrok TJH
中科院分区：
文献类型：
--
作者：
Apps R;Hawkes R;Aoki S;Bengtsson F;Brown AM;Chen G;Ebner TJ;Isope P;Jörntell H;Lackey EP;Lawrenson C;Lumb B;Schonewille M;Sillitoe RV;Spaeth L;Sugihara I;Valera A;Voogd J;Wylie DR;Ruigrok TJH
将小脑划分为模块通常用于讨论其功能。究竟什么可以被视为一个模块，它们如何运作，它们能否细分，它们是单独行动还是协同行动，这些只是本共识文件中讨论的一些关键问题。研究小脑区室化的专家们对小脑模块的结构和功能提出了自己的见解，目的是对有关这一主题的大量文献进行最新的回顾。从历史的角度来看，模块化组织的基础是由匹配橄榄皮质核连接形成的，其次是考虑解剖和化学模块化的边界，揭示了解剖，化学和生理边界之间的关系。此外，还有一个问题是，小脑的最小运作单位可能是什么。此外，浦肯野细胞的化学多样性也导致了小脑模块之间信息处理的多样性。另一个重要的考虑因素是模块划分和苔藓纤维系统的组织之间的关系，导致模块可塑性的概念。最后，检查小脑的输出模式，建议模块之间的合作和最近的工作模块方面的情绪行为进行了讨论。尽管小脑具有模块化组织这一普遍共识，但仍存在许多问题。作者希望这篇联合综述能启发未来的小脑研究，以便我们能够更好地理解这种大脑结构如何以最普遍的形式对行为做出重要贡献。
The compartmentalization of the cerebellum into modules is often used to discuss its function. What, exactly, can be considered a module, how do they operate, can they be subdivided and do they act individually or in concert are only some of the key questions discussed in this consensus paper. Experts studying cerebellar compartmentalization give their insights on the structure and function of cerebellar modules, with the aim of providing an up-to-date review of the extensive literature on this subject. Starting with an historical perspective indicating that the basis of the modular organization is formed by matching olivocorticonuclear connectivity, this is followed by consideration of anatomical and chemical modular boundaries, revealing a relation between anatomical, chemical, and physiological borders. In addition, the question is asked what the smallest operational unit of the cerebellum might be. Furthermore, it has become clear that chemical diversity of Purkinje cells also results in diversity of information processing between cerebellar modules. An additional important consideration is the relation between modular compartmentalization and the organization of the mossy fiber system, resulting in the concept of modular plasticity. Finally, examination of cerebellar output patterns suggesting cooperation between modules and recent work on modular aspects of emotional behavior are discussed. Despite the general consensus that the cerebellum has a modular organization, many questions remain. The authors hope that this joint review will inspire future cerebellar research so that we are better able to understand how this brain structure makes its vital contribution to behavior in its most general form.
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DOI：
10.1073/pnas.0808428106
发表时间：
2009-02-17
影响因子：
11.1
作者：
Bengtsson, Fredrik;Jorntell, Henrik
通讯作者：
Jorntell, Henrik
影响因子：
7.7
作者：
Ankri L;Husson Z;Pietrajtis K;Proville R;Léna C;Yarom Y;Dieudonné S;Uusisaari MY
通讯作者：
Uusisaari MY
影响因子：
2.5
作者：
Arancillo, Marife;White, Joshua J.;Sillitoe, Roy V.
通讯作者：
Sillitoe, Roy V.
影响因子：
16.2
作者：
Badura, Aleksandra;Schonewille, Martijn;De Zeeuw, Chris I.
通讯作者：
De Zeeuw, Chris I.
影响因子：
2.5
作者：
APPS, R
通讯作者：
APPS, R