Clinical Features and Prognostic Risk Prediction of Non-Hodgkin Lymphoma-Associated Hemophagocytic Syndrome.
Clinical Features and Prognostic Risk Prediction of Non-Hodgkin Lymphoma-Associated Hemophagocytic Syndrome.
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非霍奇金淋巴瘤相关噬血细胞综合征的临床特征和预后风险预测
DOI：
10.3389/fonc.2021.788056
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发表时间：
2021
影响因子：
4.7
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Yao S;Jin Z;He L;Zhang R;Liu M;Hua Z;Wang Z;Wang Y
背景恶性肿瘤，特别是淋巴瘤，是成人继发性HLH的常见原因，也是影响HLH患者预后的独立危险因素。方法选取2016年1月至2020年12月北京友谊医院收治的单纯淋巴瘤或合并淋巴瘤相关吞噬细胞综合征（LAHS）患者为研究对象。结果有348例淋巴瘤患者，104并发LAHS。无LAHS的淋巴瘤以B细胞淋巴瘤为主，而有LAHS的淋巴瘤以T/NK细胞淋巴瘤为主（P < 0.001）。浅表淋巴结肿大在B-LAHS患者中更为显著（p = 0.006），而T/NK-LAHS患者的中性粒细胞计数较低（p = 0.005），纤维蛋白原水平较低（p < 0.001），转氨酶水平较高，合并EBV感染较多（p < 0.001）。B-LAHS的IL-10水平显著高于T/NK-LAHS（p = 0.006），NK/T-LAHS的IP-10水平显著高于其他T-LAHS（p = 0.008）。年龄、血小板计数、IPI、NK/T淋巴瘤病史和HLH未缓解是非霍奇金淋巴瘤相关吞噬细胞综合征（NHL-LAHS）患者预后的独立危险因素，并建立了NHL-LAHS预后危险评分模型。结论LAHS是一种危及生命的疾病，预后差。NHL-LAHS预后风险评分模型具有较好的拟合性和验证性，具有临床应用价值。
Background Malignancies, especially lymphoma, are a common cause of adult secondary HLH and an independent risk factor for the prognosis of HLH patients. Methods Patients with lymphoma alone or concurrent lymphoma-associated phagocytic syndrome (LAHS) admitted to Beijing Friendship Hospital from January 2016 to December 2020 were enrolled in this study. Findings There were 348 lymphoma patients, 104 concurrent with LAHS. The pathological type of lymphoma without LAHS was dominated by B-cell lymphoma, while those with LAHS were T/NK-cell lymphoma predominantly (p < 0.001). Superficial lymph node enlargement was more significant in patients with B-LAHS (p = 0.006), while patients with T/NK-LAHS had lower neutrophil counts (p = 0.005), lower fibrinogen levels (p < 0.001), higher transaminase levels, and more co-infection with EBV (p < 0.001). B-LAHS had significantly higher IL-10 levels than with T/NK-LAHS (p = 0.006), and NK/T-LAHS had significantly higher IP-10 levels than other T-LAHS (p = 0.008). Age, platelet count, IPI, history of NK/T lymphoma, and no remission of HLH were independent risk factors for prognosis in patients with non-Hodgkin lymphoma-associated phagocytic syndrome (NHL-LAHS), and a prognostic risk score model for NHL-LAHS was developed. Conclusion LAHS is a life-threatening disease with a poor prognosis. The prognostic risk score model for NHL-LAHS with a good fit and validation for the test has value for clinical application.
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影响因子：
3.3
作者：
Liu, Yi-Zhen;Bi, Lan-Qing;Sun, Si
通讯作者：
Sun, Si
影响因子：
20.3
作者：
Carvelli, Julien;Piperoglou, Christelle;Kaplanski, Gilles
通讯作者：
Kaplanski, Gilles
影响因子：
11.8
作者：
Menard, Fanny;Besson, Caroline;Larroche, Claire
通讯作者：
Larroche, Claire
成人对恶性相关的淋巴淋巴虫组织细胞增多症的共识综述。
影响因子：
6.2
作者：
Daver N;McClain K;Allen CE;Parikh SA;Otrock Z;Rojas-Hernandez C;Blechacz B;Wang S;Minkov M;Jordan MB;La Rosée P;Kantarjian HM
通讯作者：
Kantarjian HM
影响因子：
3.5
作者：
Maruoka, Hayato;Inoue, Daichi;Takiuchi, Yoko;Nagano, Seiji;Arima, Hiroshi;Tabata, Sumie;Matsushita, Akiko;Ishikawa, Takayuki;Oita, Tatsuo;Takahashi, Takayuki
通讯作者：
Takahashi, Takayuki