IP-10/CXCL10 and MIG/CXCL9 as novel markers for the diagnosis of lymphoma-associated hemophagocytic syndrome.
IP-10/CXCL10 and MIG/CXCL9 as novel markers for the diagnosis of lymphoma-associated hemophagocytic syndrome.
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DOI：
10.1007/s00277-013-1878-y
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发表时间：
2014-03
影响因子：
3.5
通讯作者：
Takahashi, Takayuki
中科院分区：
文献类型：
--
作者：
Maruoka, Hayato;Inoue, Daichi;Takiuchi, Yoko;Nagano, Seiji;Arima, Hiroshi;Tabata, Sumie;Matsushita, Akiko;Ishikawa, Takayuki;Oita, Tatsuo;Takahashi, Takayuki
淋巴瘤相关噬血细胞综合征（LAHS）是一种严重的疾病，早期诊断和适当的化疗是非常重要的。然而，LAHS早期诊断的可靠标志物尚未确定。我们使用新引入的检测系统，流式细胞仪珠阵列（CBA）筛选血清细胞因子，并确定干扰素诱导蛋白10（IP-10）/CXCL 10和干扰素γ（IFN-γ）/CXCL 9诱导的单核细胞因子作为有用的标志物。在LAHS诊断时，IP-10和IL 10的血清浓度分别大于500和5，000 pg/ml。当我们将上述值设定为临界值时，LAHS诊断的敏感性和特异性分别为100%和95%。这两种趋化因子的血清水平在入院时已经升高，并在成功治疗后显著降低，表明它们对LAHS的诊断和治疗结果都有用。IP-10和RAHS也可用于区分重度和中度/轻度LAHS，以及B细胞型LAHS和T细胞/自然杀伤细胞型LAHS。此外，IP-10和ESTA用于区分LAHS与败血症的血液恶性肿瘤患者。CBA快速检测IP-10和CRP对LAHS的早期诊断和治疗有重要意义。
Lymphoma-associated hemophagocytic syndrome (LAHS) is a serious disorder, and its early diagnosis and treatment with appropriate chemotherapy are very important. However, reliable markers for early diagnosis of LAHS have not been identified. We screened serum cytokines using a newly introduced assay system, cytometric bead array (CBA), and identified interferon-inducible protein 10 (IP-10)/CXCL10 and monokine induced by interferon gamma (MIG)/CXCL9 as useful markers. Serum concentrations of IP-10 and MIG at the time of LAHS diagnosis were greater than 500 and 5,000 pg/ml, respectively. The sensitivity and specificity for LAHS diagnosis were 100 and 95 %, respectively, when we set the above values as the cut-off levels. Serum levels of these two chemokines were already elevated at the time of admission and significantly decreased after successful treatment, indicating their usefulness for both the diagnosis and therapeutic outcomes for LAHS. IP-10 and MIG were also useful in distinguishing severe from moderate/mild LAHS, and B-cell-type LAHS from T-cell/natural killer cell-type LAHS. Furthermore, IP-10 and MIG were of use to distinguish LAHS from sepsis in patients with hematologic malignancies. Rapid measurement of IP-10 and MIG by CBA appeared to be important for early diagnosis and treatment of LAHS.
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DOI：
10.1532/lh96.05035
发表时间：
2006-01-01
期刊：
Laboratory hematology : official publication of the International Society for Laboratory Hematology
影响因子：
--
作者：
Murohashi, Ikuo;Yoshida, Katsuhiko;Bessho, Masami
通讯作者：
Bessho, Masami
影响因子：
8.6
作者：
Morgan, E;Varro, R;Gaur, A
通讯作者：
Gaur, A
影响因子：
15.3
作者：
Bonecchi, R;Bianchi, G;Bordignon, P P;D'Ambrosio, D;Lang, R;Borsatti, A;Sozzani, S;Allavena, P;Gray, P A;Mantovani, A;Sinigaglia, F
通讯作者：
Sinigaglia, F
影响因子：
2.2
作者：
Cook, EB;Stahl, JL;Barney, NP
通讯作者：
Barney, NP
影响因子：
20.3
作者：
HENTER, JI;ELINDER, G;ANDERSSON, U
通讯作者：
ANDERSSON, U