The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model.
The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model.
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免疫调节性寄生虫蠕虫产物ES-62减少了小鼠模型中与狼疮相关的动脉粥样硬化。
DOI：
10.1016/j.ijpara.2014.12.006
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发表时间：
2015-03
影响因子：
4
通讯作者：
Rifkin, Ian R.
中科院分区：
文献类型：
--
作者：
Aprahamian, Tamar R.;Zhong, Xuemei;Amir, Shahzada;Binder, Christoph J.;Chiang, Lo-Ku;Al-Riyami, Lamyaa;Gharakhanian, Raffi;Harnett, Margaret M.;Harnett, William;Rifkin, Ian R.
ES-62是一种由丝虫Acanthocheilonema viteae分泌的含有磷酸胆碱的抗炎糖蛋白。系统性红斑狼疮（SLE）患者常发生加速性动脉粥样硬化，导致心血管疾病的发病率和死亡率。我们研究了ES-62在这种疾病的gld.apoE−/−小鼠模型中的作用。用ES-62治疗基本上不调节肾脏病理学，但引起抗核自身抗体水平降低。此外，观察到主动脉粥样硬化病变显著减少60%，巨噬细胞和纤维化相关减少。我们认为，后者的研究结果构成了第一个例子，一个明确的寄生虫产品在动脉粥样硬化的治疗潜力：ES-62为基础的药物可能代表了一种新的方法来控制加速动脉粥样硬化系统性红斑狼疮。
ES-62 is an anti-inflammatory phosphorylcholine-containing glycoprotein secreted by the filarial nematode Acanthocheilonema viteae. Accelerated atherosclerosis frequently occurs in systemic lupus erythematosus (SLE), resulting in substantial cardiovascular morbidity and mortality. We examined the effects of ES-62 in the gld.apoE−/− mouse model of this condition. Treatment with ES-62 did not substantially modulate renal pathology but caused decreased anti-nuclear autoantibody levels. Moreover, a striking 60% reduction in aortic atherosclerotic lesions was observed, with an associated decrease in macrophages and fibrosis. We believe that these latter findings constitute the first example of a defined parasitic worm product with therapeutic potential in atherosclerosis: ES-62-based drugs may represent a novel approach to control accelerated atherosclerosis in SLE.
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影响因子：
5.3
作者：
Stanley, Ronald G.;Jackson, Christopher L.;Doenhoff, Michael J.
通讯作者：
Doenhoff, Michael J.
DOI：
10.1111/j.1440-1681.2006.04400.x
发表时间：
2006-05-01
影响因子：
2.9
作者：
Harnett, W;Harnett, MM
通讯作者：
Harnett, MM
影响因子：
5.3
作者：
Su, Jun;Georgiades, Anastasia;Frostegard, Johan
通讯作者：
Frostegard, Johan
DOI：
10.4269/ajtmh.2010.10-0410
发表时间：
2010-12-01
影响因子：
3.3
作者：
Aravindhan, Vivekanandhan;Mohan, Vishwanathan;Babu, Subash
通讯作者：
Babu, Subash
影响因子：
82.9
作者：
Binder, CJ;Hörkkö, S;Silverman, GJ
通讯作者：
Silverman, GJ