More than Meets the Eye: The Aryl Hydrocarbon Receptor is an Environmental Sensor, Physiological Regulator and a Therapeutic Target in Ocular Disease.
More than Meets the Eye: The Aryl Hydrocarbon Receptor is an Environmental Sensor, Physiological Regulator and a Therapeutic Target in Ocular Disease.
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DOI：
10.3389/ftox.2022.791082
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发表时间：
2022
影响因子：
--
通讯作者：
Woeller CF
中科院分区：
文献类型：
--
作者：
Hammond CL;Roztocil E;Gupta V;Feldon SE;Woeller CF
芳烃受体（AHR）是一种配体激活的转录因子，最初被鉴定为外源性化学物质的环境传感器。然而，研究表明，AHR调节细胞生长和代谢，发育和免疫系统的关键方面。AHR和AHR信号在眼睛发育、毒理学和疾病中的重要性正在被发现。AHR在许多眼组织中表达，包括视网膜、脉络膜、角膜和眼眶。AHR在年龄相关性黄斑变性（AMD）、自身免疫性葡萄膜炎和其他眼部疾病中的重要作用已经被确定。AHR的配体是来自外源性和内源性来源的结构多样的有机分子。天然AHR配体包括色氨酸的代谢物和微生物组的副产物。异源AHR配体包括持久性环境污染物，如二恶英、苯并（a）芘[B（a）P]和多氯联苯（PCB）。包括质子泵抑制剂埃索美拉唑和兰索拉唑以及免疫抑制剂来氟米特在内的药物可激活AHR。在这篇综述中，我们强调了AHR在眼睛中的作用，并讨论了AHR信号是如何参与对内源性和环境刺激的反应。我们还提出了一个新的概念，即AHR是一个有前途的治疗眼病的目标。
The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor originally identified as an environmental sensor of xenobiotic chemicals. However, studies have revealed that the AHR regulates crucial aspects of cell growth and metabolism, development and the immune system. The importance of the AHR and AHR signaling in eye development, toxicology and disease is now being uncovered. The AHR is expressed in many ocular tissues including the retina, choroid, cornea and the orbit. A significant role for the AHR in age-related macular degeneration (AMD), autoimmune uveitis, and other ocular diseases has been identified. Ligands for the AHR are structurally diverse organic molecules from exogenous and endogenous sources. Natural AHR ligands include metabolites of tryptophan and byproducts of the microbiome. Xenobiotic AHR ligands include persistent environmental pollutants such as dioxins, benzo (a) pyrene [B (a) P] and polychlorinated biphenyls (PCBs). Pharmaceutical agents including the proton pump inhibitors, esomeprazole and lansoprazole, and the immunosuppressive drug, leflunomide, activate the AHR. In this review, we highlight the role of the AHR in the eye and discuss how AHR signaling is involved in responding to endogenous and environmental stimuli. We also present the emerging concept that the AHR is a promising therapeutic target for eye disease.
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影响因子：
3
作者：
Araj H;Tumminia SJ;Yeung DT
通讯作者：
Yeung DT
人虹膜和视网膜色素上皮的比较基因表达研究和途径分析。
影响因子：
3.7
作者：
Bennis A;Ten Brink JB;Moerland PD;Heine VM;Bergen AA
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Bergen AA
影响因子：
7.8
作者：
Cella M;Colonna M
通讯作者：
Colonna M
DOI：
10.1165/rcmb.2014-0142oc
发表时间：
2015-03-01
影响因子：
6.4
作者：
Awji, Elias G.;Chand, Hitendra;Tesfaigzi, Yohannes
通讯作者：
Tesfaigzi, Yohannes
影响因子：
3.7
作者：
Chevallier A;Mialot A;Petit JM;Fernandez-Salguero P;Barouki R;Coumoul X;Beraneck M
通讯作者：
Beraneck M