Calcium, ARMS2 genotype, and Chlamydia pneumoniae infection in early age-related macular degeneration: a multivariate analysis from the Nagahama study.
Calcium, ARMS2 genotype, and Chlamydia pneumoniae infection in early age-related macular degeneration: a multivariate analysis from the Nagahama study.
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DOI：
10.1038/srep09345
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发表时间：
2015-03-20
影响因子：
4.6
通讯作者：
Nagahama Study Group
中科院分区：
文献类型：
--
作者：
Nakata I;Yamashiro K;Kawaguchi T;Nakanishi H;Akagi-Kurashige Y;Miyake M;Tsujikawa A;Yamada R;Matsuda F;Yoshimura N;Nagahama Study Group
尽管各种危险因素已被确定为老年性黄斑变性(AMD)的发生，但对早期AMD的危险因素研究相对较少。我们旨在通过同时评估与AMD的重要组成部分大玻璃体相关的多个因素来调查AMD的危险因素。在日本的一项基于社区的横断面调查中，对971例大型玻璃疱疹病例和3209例对照进行了65个变量的比较，包括系统、环境和遗传因素。各因素的关联性和效应大小采用Logistic回归分析，采用后向剔除方法进行评估。多因素分析显示，血清钙水平(优势比[OR]=0.932，P=1.05×10−3)、ARMS2A69S(Rs10490924)、肺炎衣原体Ig G(OR=1.020，P=0.0440)、年龄(OR=1.013，P<；0.001)与血清钙水平显著相关。大玻璃疣患者低钙血症发生率为7.2%，对照组为5.5%(P=0.0490)。大型玻璃体病人肺炎衣原体感染发生率(56.4%)明显高于对照组(51.7%，P=0.00956)。这些结果提示钙、ARMS2基因、肺炎链球菌感染和年龄是AMD早期发展的重要因素。
Although various risk factors have been identified for the development of age-related macular degeneration (AMD), risk factors of early AMD have been relatively under studied. We aimed to investigate AMD risk factors by evaluating multiple factors in association with large drusen, an important component of AMD, simultaneously. In a community-based cross-sectional survey in Japan, 971 large drusen cases and 3,209 controls were compared for 65 variables, including systemic, environmental, and genetic factors. The association and the effect size of each factor were evaluated with logistic regression analysis using a backward-elimination approach. Multivariate analyses identified a significant association in serum calcium level (odds ratio [OR] = 0.932, P = 1.05 × 10−3), ARMS2 A69S (rs10490924) genotype (OR = 1.046, P < 0.001), Chlamydia pneumoniae IgG (OR = 1.020, P = 0.0440), and age (OR = 1.013, P < 0.001) for large drusen. Hypocalcemia was observed in 7.2% of large drusen cases and in 5.5% of controls (P = 0.0490). C. pneumoniae infections was more frequent in large drusen cases (56.4%) than in conrols (51.7%, P = 0.00956). These results suggest that calcium, ARMS2 genotype, C. pneumonia infection, and age are significant factors in the development of the early stages of AMD.
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DOI：
10.1038/eye.2008.422
发表时间：
2009-12
期刊：
Eye (London, England)
影响因子：
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作者：
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DOI：
10.1073/pnas.1114759108
发表时间：
2011-11-01
影响因子：
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DOI：
10.1007/s00417-005-1169-y
发表时间：
2005-11-01
影响因子：
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作者：
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