The role of brain-derived neurotrophic factor genotype, parental depression, and relationship discord in predicting early-emerging negative emotionality.
The role of brain-derived neurotrophic factor genotype, parental depression, and relationship discord in predicting early-emerging negative emotionality.
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DOI：
10.1177/0956797610385357
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发表时间：
2010-11
影响因子：
8.2
通讯作者：
Singh SM
中科院分区：
文献类型：
--
作者：
Hayden EP;Klein DN;Dougherty LR;Olino TM;Dyson MW;Durbin CE;Sheikh HI;Singh SM
The brain-derived neurotrophic factor (BDNF) gene is a plausible candidate for early-emerging negative emotionality (NE), and evidence suggests that the effects of this gene may be especially salient in the context of familial risk for child maladjustment. We therefore examined whether the BDNF val66met polymorphism was associated with child NE in the context of parental depression and relationship discord. A sample of 413 three-year-old children was assessed for NE using standardized laboratory measures. Parents completed clinical interviews and a measure of marital satisfaction. Children with at least one BDNF met allele exhibited elevated NE when a parent had a history of depressive disorder, or when relationship discord was present. In contrast, this allele was associated with especially low NE when parent depression was absent, and when the parental relationship was not discordant. Findings suggest that the BDNF met allele confers increased child sensitivity to both positive and negative familial influences.
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影响因子：
10.6
作者：
Kaufman, J;Yang, BZ;Gelernter, J
通讯作者：
Gelernter, J
影响因子：
6
作者：
Glenn, ND
通讯作者：
Glenn, ND
影响因子：
4
作者：
Goldsmith, HH;Buss, KA;Lemery, KS
通讯作者：
Lemery, KS
DOI：
10.1207/153744202320802151
发表时间：
2002-12-01
影响因子：
4.2
作者：
Anthony, JL;Lonigan, CJ;Phillips, BM
通讯作者：
Phillips, BM
影响因子：
--
作者：
Kendler, Kenneth S.;Gatz, Margaret;Pedersen, Nancy L.
通讯作者：
Pedersen, Nancy L.