Odours of Plasmodium falciparum-infected participants influence mosquito-host interactions.
Odours of Plasmodium falciparum-infected participants influence mosquito-host interactions.
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疟原虫感染的参与者的气味会影响蚊子 - 宿主相互作用。
DOI：
10.1038/s41598-017-08978-9
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发表时间：
2017-08-24
影响因子：
4.6
通讯作者：
Logan JG
中科院分区：
文献类型：
--
作者：
de Boer JG;Robinson A;Powers SJ;Burgers SLGE;Caulfield JC;Birkett MA;Smallegange RC;van Genderen PJJ;Bousema T;Sauerwein RW;Pickett JA;Takken W;Logan JG
疟疾寄生虫被认为会影响蚊子对人类宿主的吸引力，这种现象可能会增强寄生虫的传播。这可能是介导的宿主气味的改变，因为它在蚊子宿主搜索行为的重要性。在这里，我们报告说，人类皮肤的气味分布受到疟疾感染。我们比较了化学成分和吸引力按蚊coluzzii蚊子的皮肤气味的参与者，感染了控制人类疟疾感染恶性疟原虫。皮肤气味组成不同的寄生虫阴性和阳性样本，阳性样本收集后，平均两天的寄生虫出现从肝脏进入血液，与低密度的无性寄生虫和配子体的情况下。我们发现，在一个实验感染过程中，蚊子对皮肤气味的吸引力显着减少，但在第二个实验中没有，可能是由于寄生虫株的差异。然而，它确实增加了感染可能影响蚊子行为的可能性。事实上，已鉴定出几种可影响蚊子行为的挥发性化合物，包括2-和3-甲基丁醛、3-羟基-2-丁酮和6-甲基-5-庚烯-2-酮。为了更好地了解我们的研究结果对疟原虫传播的影响，需要在配子体和较高寄生虫密度的参与者中进行对照研究。
Malaria parasites are thought to influence mosquito attraction to human hosts, a phenomenon that may enhance parasite transmission. This is likely mediated by alterations in host odour because of its importance in mosquito host-searching behaviour. Here, we report that the human skin odour profile is affected by malaria infection. We compared the chemical composition and attractiveness to Anopheles coluzzii mosquitoes of skin odours from participants that were infected by Controlled Human Malaria Infection with Plasmodium falciparum. Skin odour composition differed between parasitologically negative and positive samples, with positive samples collected on average two days after parasites emerged from the liver into the blood, being associated with low densities of asexual parasites and the absence of gametocytes. We found a significant reduction in mosquito attraction to skin odour during infection for one experiment, but not in a second experiment, possibly due to differences in parasite strain. However, it does raise the possibility that infection can affect mosquito behaviour. Indeed, several volatile compounds were identified that can influence mosquito behaviour, including 2- and 3-methylbutanal, 3-hydroxy-2-butanone, and 6-methyl-5-hepten-2-one. To better understand the impact of our findings on Plasmodium transmission, controlled studies are needed in participants with gametocytes and higher parasite densities.
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影响因子：
9.8
作者：
通讯作者：
--
DOI：
10.1073/pnas.1405617111
发表时间：
2014-07-29
影响因子：
11.1
作者：
De Moraes, Consuelo M.;Stanczyk, Nina M.;Mescher, Mark C.
通讯作者：
Mescher, Mark C.
影响因子：
3.2
作者：
Batista, Elis P. A.;Costa, Elizangela F. M.;Silva, Alexandre A.
通讯作者：
Silva, Alexandre A.
影响因子：
2.4
作者：
BAYLIS, M;NAMBIRO, CO
通讯作者：
NAMBIRO, CO
影响因子：
1.9
作者：
Moloo, SK;Sabwa, CL;Baylis, M
通讯作者：
Baylis, M