Neural pathways that control the glucose counterregulatory response.
Neural pathways that control the glucose counterregulatory response.
复制标题
控制葡萄糖反应反应的神经途径。
DOI：
10.3389/fnins.2014.00038
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发表时间：
2014
影响因子：
4.3
通讯作者：
Korim WS
中科院分区：
文献类型：
--
作者：
Verberne AJ;Sabetghadam A;Korim WS
葡萄糖是所有身体组织必需的代谢底物。大脑尤其依赖于葡萄糖的持续供应来满足其能量需求。幸运的是，一个复杂的生理系统已经进化，可以将血糖保持在恒定水平。葡萄糖稳态不良的后果是众所周知的：与不受控制的糖尿病相关的高血糖可导致心血管疾病、神经病和肾病，而低血糖可导致抽搐、意识丧失、昏迷甚至死亡。葡萄糖反调节反应包括检测血浆葡萄糖水平下降和分泌多种激素，包括胰高血糖素、肾上腺素、皮质醇和生长激素 (GH)，以协调低血糖的恢复。低血糖会导致低脑葡萄糖水平，这是由位于多个大脑区域的葡萄糖感应神经元检测到的，例如下丘脑腹内侧、下丘脑外侧的穹窿周区域、弓状核（ARC）和几个后脑区域。这篇综述将描述葡萄糖反调节系统的重要性以及支撑它的神经回路的已知信息。
Glucose is an essential metabolic substrate for all bodily tissues. The brain depends particularly on a constant supply of glucose to satisfy its energy demands. Fortunately, a complex physiological system has evolved to keep blood glucose at a constant level. The consequences of poor glucose homeostasis are well-known: hyperglycemia associated with uncontrolled diabetes can lead to cardiovascular disease, neuropathy and nephropathy, while hypoglycemia can lead to convulsions, loss of consciousness, coma, and even death. The glucose counterregulatory response involves detection of declining plasma glucose levels and secretion of several hormones including glucagon, adrenaline, cortisol, and growth hormone (GH) to orchestrate the recovery from hypoglycemia. Low blood glucose leads to a low brain glucose level that is detected by glucose-sensing neurons located in several brain regions such as the ventromedial hypothalamus, the perifornical region of the lateral hypothalamus, the arcuate nucleus (ARC), and in several hindbrain regions. This review will describe the importance of the glucose counterregulatory system and what is known of the neurocircuitry that underpins it.
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影响因子：
56.9
作者：
AMOROSO, S;SCHMIDANTOMARCHI, H;LAZDUNSKI, M
通讯作者：
LAZDUNSKI, M
影响因子：
5.5
作者：
BLOOM, SR;EDWARDS, AV
通讯作者：
EDWARDS, AV
影响因子：
2.5
作者：
ADACHI, A
通讯作者：
ADACHI, A
DOI：
10.1111/j.1440-1681.1996.tb02590.x
发表时间：
1996-02-01
影响因子：
2.9
作者：
Blair, ML;Piekut, D;Olschowka, JA
通讯作者：
Olschowka, JA
影响因子：
5.5
作者：
BLOOM, SR;EDWARDS, AV;VAUGHAN, NJA
通讯作者：
VAUGHAN, NJA