Unique temporal and spatial expression patterns of IL-33 in ovaries during ovulation and estrous cycle are associated with ovarian tissue homeostasis.
Unique temporal and spatial expression patterns of IL-33 in ovaries during ovulation and estrous cycle are associated with ovarian tissue homeostasis.
复制标题
排卵和发情循环期间IL-33的独特时间和空间表达模式与卵巢组织稳态有关。
DOI：
10.4049/jimmunol.1400381
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发表时间：
2014-07-01
期刊：
影响因子：
--
通讯作者：
Lou Y
中科院分区：
文献类型：
--
作者：
Carlock CI;Wu J;Zhou C;Tatum K;Adams HP;Tan F;Lou Y
Ovaries are among the most active organs. Frequently occurring events such as ovulation and ovarian atresia are accompanied with tissue destruction and repairing. Critical roles of immune cells or molecules in those events have been well recognized. Interleukin 33 (IL33) is a new member of IL1 cytokine gene family. Recent studies suggest its roles beyond immune responses. We systemically examined its expression in ovaries for its potential roles in ovarian functions. During ovulation, a high level of IL33 was transiently expressed, making it the most significantly up-regulated immune genes. During estrous cycle, IL33 expression levels fluctuated along with numbers of ovarian macrophages and atresia wave. Cells with nuclear form of IL33 (nIL33+ cells) were mostly endothelial cells of veins, either in the inner layer of theca of ovulating follicles during ovulation, or surrounding follicles during estrous cycle. Changes in number of nIL33+ cells showed a tendency similar to that in IL33 mRNA level during estrous cycle. However, the cell number sharply dropped before a rapid increase of macrophages and surge of atresia. The drop in nIL33+ cell number was coincident with detection of higher level of the cytokine form of IL33 by western blot, suggesting a release of cytokine form of IL33 before the surge of macrophage migration and atresia. However, IL33 Ab, either by passive transfer or immunization, showed a limited effect on ovulation or atresia. It raises a possibility of IL33’s role in tissue homeostasis following ovarian events, instead of a direct involvement in ovarian functions.
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DOI：
10.1073/pnas.0812690106
发表时间：
2009-06-02
影响因子：
11.1
作者：
Cayrol, Corinne;Girard, Jean-Philippe
通讯作者：
Girard, Jean-Philippe
影响因子：
3.6
作者：
BRANNSTROM, M;MAYRHOFER, G;ROBERTSON, SA
通讯作者：
ROBERTSON, SA
DOI：
10.1530/jrf.0.0960241
发表时间：
1992-09-01
期刊：
JOURNAL OF REPRODUCTION AND FERTILITY
影响因子：
--
作者：
FUKUMATSU, Y;KATABUCHI, H;OKAMURA, H
通讯作者：
OKAMURA, H
影响因子：
6
作者：
Baekkevold, ES;Roussigné, M;Girard, JP
通讯作者：
Girard, JP
影响因子：
5.5
作者：
Borish, Larry;Steinke, John W.
通讯作者：
Steinke, John W.