Acute Cortisol Profile Associations With Cognitive Impairment After Severe Traumatic Brain Injury.
Acute Cortisol Profile Associations With Cognitive Impairment After Severe Traumatic Brain Injury.
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DOI：
10.1177/15459683211048771
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发表时间：
2021-12
影响因子：
4.2
通讯作者：
Wagner AK
中科院分区：
文献类型：
--
作者：
Barton DJ;Kumar RG;Schuster AA;Juengst SB;Oh BM;Wagner AK
认知障碍通常发生在创伤性脑损伤（TBI）后，并影响日常功能。皮质醇水平在严重TBI后的大多数人急性住院期间升高，可以影响认知，但这种关联以前在TBI中没有研究过。我们假设，血清和脑脊髓液（CSF）皮质醇轨迹0-5天损伤后与认知损伤后6个月。我们检查了94名严重TBI的参与者，在受伤后0-5天收集了急性血清和/或CSF样本，并将皮质醇水平与17名健康对照者进行了比较。N=88名参与者有血清，N=84名参与者有CSF样本可用于皮质醇测量，并在损伤后6个月进行神经心理学测试。基于组的轨迹分析（TRAJ）被用来产生时间血清和CSF皮质醇的档案，检查与神经心理性能的关联。我们使用线性回归来研究皮质醇TRAJ组与整体和特定领域认知之间的关系。TRAJ分析确定了血清的高组和下降组以及CSF皮质醇的高组和低组。多变量分析显示，血清皮质醇TRAJ组与总体认知综合评分（p=0.024）、执行功能（p=0.039）和语言流畅性（p=0.029）领域评分相关。CSF皮质醇TRAJ组与总体认知综合评分（p=0.021）和执行功能（p=0.041）、语言流畅性（p=0.031）和注意力（p=0.034）的领域评分相关。高急性皮质醇轨迹与TBI后6个月认知能力较差相关。
Cognitive impairments commonly occur after traumatic brain injury (TBI) and affect daily functioning. Cortisol levels, which are elevated during acute hospitalization for most individuals after severe TBI, can influence cognition, but this association has not been studied previously in TBI. We hypothesized that serum and cerebral spinal fluid (CSF) cortisol trajectories over days 0–5 post-injury are associated with cognition 6-months post-injury. We examined 94 participants with severe TBI, collected acute serum and/or CSF samples over days 0–5 post-injury, and compared cortisol levels to those in 17 healthy controls. N=88 participants had serum, and n=84 had CSF samples available for cortisol measurement and had neuropsychological testing 6-months post-injury. Group based trajectory analysis (TRAJ) was used to generate temporal serum and CSF cortisol profiles which were examined for associations with neuropsychological performance. We used linear regression to examine relationships between cortisol TRAJ groups and both overall and domain-specific cognition. TRAJ analysis identified a high group and a decliner group for serum and a high group and low group for CSF cortisol. Multivariable analysis showed serum cortisol TRAJ group was associated with overall cognitive composites scores (p=0.024) and with executive function (p=0.039) and verbal fluency (p=0.029) domain scores. CSF cortisol TRAJ group was associated with overall cognitive composite scores (p=0.021) and domain scores for executive function (p=0.041), verbal fluency (p=0.031), and attention (p=0.034). High acute cortisol trajectories are associated with poorer cognition 6-months post-TBI.
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影响因子：
11.2
作者：
Cole, James H.;Leech, Robert;Sharp, David J.
通讯作者：
Sharp, David J.
DOI：
10.2201/nonlin.003.01.004
发表时间：
2005-01-01
期刊：
Nonlinearity in Biology Toxicology and Medicine
影响因子：
--
作者：
Conrad, Cheryl D.
通讯作者：
Conrad, Cheryl D.
影响因子：
4.8
作者：
Karssen, AM;Meijer, OC;de Kloet, ER
通讯作者：
de Kloet, ER
影响因子：
9.3
作者：
Dong T;Zhi L;Bhayana B;Wu MX
通讯作者：
Wu MX
影响因子：
3.3
作者：
Griesbach, G. S.;Vincelli, J.;Hovda, D. A.
通讯作者：
Hovda, D. A.