Ketamine normalizes high-gamma power in the anterior cingulate cortex in a rat chronic pain model.
Ketamine normalizes high-gamma power in the anterior cingulate cortex in a rat chronic pain model.
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DOI：
10.1186/s13041-020-00670-w
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发表时间：
2020-09-23
期刊：
影响因子：
3.6
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Friesner ID;Martinez E;Zhou H;Gould JD;Li A;Chen ZS;Zhang Q;Wang J
慢性疼痛改变了皮层和皮层下的可塑性，导致对外周伤害性输入的感觉和情感反应增强。先前的研究表明，氯胺酮有可能通过抑制前扣带皮层（ACC）的过度活跃来抑制单个神经元异常放大的情感反应。然而，这种持久效应的机制尚未在网络层面上得到理解。在本研究中，我们记录了自由运动大鼠ACC的局部场电位。动物注射完全弗氏佐剂（CFA）诱导持续性炎性疼痛。在给药前后分别对后爪进行机械刺激。我们发现，CFA治疗后诱发疼痛的高伽马波段（60-100 Hz）功率显著增加。然而，氯胺酮降低了cfa治疗大鼠对诱发疼痛的高伽马波段功率。此外，氯胺酮对高伽马波段功率的持续影响在单次给药后可持续5天。这些结果表明氯胺酮有可能改变慢性疼痛引起的ACC中的不适应神经反应。
Chronic pain alters cortical and subcortical plasticity, causing enhanced sensory and affective responses to peripheral nociceptive inputs. Previous studies have shown that ketamine had the potential to inhibit abnormally amplified affective responses of single neurons by suppressing hyperactivity in the anterior cingulate cortex (ACC). However, the mechanism of this enduring effect has yet to be understood at the network level. In this study, we recorded local field potentials from the ACC of freely moving rats. Animals were injected with complete Freund’s adjuvant (CFA) to induce persistent inflammatory pain. Mechanical stimulations were administered to the hind paw before and after CFA administration. We found a significant increase in the high-gamma band (60–100 Hz) power in response to evoked pain after CFA treatment. Ketamine, however, reduced the high-gamma band power in response to evoked pain in CFA-treated rats. In addition, ketamine had a sustained effect on the high-gamma band power lasting up to five days after a single dose administration. These results demonstrate that ketamine has the potential to alter maladaptive neural responses in the ACC induced by chronic pain.
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DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
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作者：
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DOI：
10.1017/s1461145714000959
发表时间：
2014-11-01
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