Sensation-to-cognition cortical streams in attention-deficit/hyperactivity disorder.
Sensation-to-cognition cortical streams in attention-deficit/hyperactivity disorder.
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DOI：
10.1002/hbm.22790
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发表时间：
2015-07
影响因子：
4.8
通讯作者：
Sepulcre, Jorge
中科院分区：
文献类型：
--
作者：
Carmona, Susana;Hoekzema, Elseline;Castellanos, Francisco X.;Garcia-Garcia, David;Lage-Castellanos, Agustin;Van Dijk, Koene R. A.;Navas-Sanchez, Francisco J.;Martinez, Kenia;Desco, Manuel;Sepulcre, Jorge
关键词：
我们试图确定连接感觉、注意力和高阶认知回路的功能连接流在注意力缺陷/多动障碍（ADHD）中是否是非典型的。我们应用图论方法对120名ADHD儿童和120名年龄匹配的典型发育儿童（TDC）的静息态功能磁共振成像数据进行分析。从单峰初级皮层视觉，听觉和体感开始，我们使用逐步功能连接计算功能连接路径在离散数量的中继站（或链接步距离）。首先，我们描述了TDC中连接感觉、注意力和高阶认知回路的功能连接流，发现系统没有达到成年人所达到的整合水平。其次，我们寻找ADHD和TDC儿童之间的逐步功能连接差异。我们发现，在感觉功能连接流的初始步骤中，患者显示出初级皮层相邻区域内的连接程度显著增强，而与注意力调节区域的连接减少。第三，在随后的初级感觉皮层的链接步骤的距离，ADHD儿童表现出减少连接到执行处理区和增加程度的连接到默认模式区域。第四，在检查ADHD儿童的用药史时，我们发现，与未用药儿童相比，使用精神兴奋剂的儿童呈现出与注意力和执行过程相关区域的功能连接流。我们的结论是，占主导地位的本地感觉处理和较少的信息流入注意力和执行区域可能会降低组织和控制ADHD的外部和内部信息源之间的平衡的能力。
We sought to determine whether functional connectivity streams that link sensory, attentional, and higher-order cognitive circuits are atypical in attention-deficit/hyperactivity disorder (ADHD). We applied a graph-theory method to the resting-state functional magnetic resonance imaging data of 120 children with ADHD and 120 age-matched typically developing children (TDC). Starting in unimodal primary cortex—visual, auditory, and somatosensory—we used stepwise functional connectivity to calculate functional connectivity paths at discrete numbers of relay stations (or link-step distances). First, we characterized the functional connectivity streams that link sensory, attentional, and higher-order cognitive circuits in TDC and found that systems do not reach the level of integration achieved by adults. Second, we searched for stepwise functional connectivity differences between children with ADHD and TDC. We found that, at the initial steps of sensory functional connectivity streams, patients display significant enhancements of connectivity degree within neighboring areas of primary cortex, while connectivity to attention-regulatory areas is reduced. Third, at subsequent link-step distances from primary sensory cortex, children with ADHD show decreased connectivity to executive processing areas and increased degree of connections to default mode regions. Fourth, in examining medication histories in children with ADHD, we found that children medicated with psychostimulants present functional connectivity streams with higher degree of connectivity to regions subserving attentional and executive processes compared to medication-naïve children. We conclude that predominance of local sensory processing and lesser influx of information to attentional and executive regions may reduce the ability to organize and control the balance between external and internal sources of information in ADHD.
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影响因子：
10.6
作者：
Fair, Damien A.;Posner, Jonathan;Nagel, Bonnie J.;Bathula, Deepti;Dias, Taciana G. Costa;Mills, Kathryn L.;Blythe, Michael S.;Giwa, Aishat;Schmitt, Colleen F.;Nigg, Joel T.
通讯作者：
Nigg, Joel T.
影响因子：
0.5
作者：
KAMADA, T;KAWAI, S
通讯作者：
KAWAI, S
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
1.7
作者：
Cao, Qingjiu;Zang, Yufeng;Wang, Yufeng
通讯作者：
Wang, Yufeng
自闭症和注意力缺陷/多动障碍中共享和独特的内在功能网络中心性
影响因子：
10.6
作者：
Di Martino A;Zuo XN;Kelly C;Grzadzinski R;Mennes M;Schvarcz A;Rodman J;Lord C;Castellanos FX;Milham MP
通讯作者：
Milham MP