Atypical default network connectivity in youth with attention-deficit/hyperactivity disorder.
Atypical default network connectivity in youth with attention-deficit/hyperactivity disorder.
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DOI：
10.1016/j.biopsych.2010.07.003
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发表时间：
2010-12-15
影响因子：
10.6
通讯作者：
Nigg, Joel T.
中科院分区：
文献类型：
--
作者：
Fair, Damien A.;Posner, Jonathan;Nagel, Bonnie J.;Bathula, Deepti;Dias, Taciana G. Costa;Mills, Kathryn L.;Blythe, Michael S.;Giwa, Aishat;Schmitt, Colleen F.;Nigg, Joel T.
注意缺陷/多动障碍（ADHD）是一个主要的公共卫生问题。有人认为，大脑的默认网络可能为理解多动症的神经生物学提供了一个重要途径。近年来，静息状态功能连接MRI （rs-fcMRI）技术的应用增加了对默认网络的评估。这些调查已经证实，该网络的自发活动在年轻成人人群中是高度相关的。这种一致性似乎在患有多动症的成年人身上有所降低。这是一个有趣的发现，因为默认网络中自发活动的一致性随着年龄的增长而增强。因此，ADHD的病理生理学可能包括默认网络成熟的延迟或中断。如果是这样，那么重要的是确定是否可以使用rs-fcMRI检测ADHD儿童的发育图景。本研究利用Fair等人先前提供的典型发育背景，在患有（n=23）和非ADHD （n=23）的儿童中使用rs-fcMRI检查默认网络内大脑活动的一致性。我们发现，先前在默认网络中显示为发育动态的功能连接在ADHD儿童中是非典型的-与成熟过程的扰动或失败一致。这些发现与该网络在发育过程中的非典型巩固在ADHD中起作用的假设是一致的。
Attention deficit/hyperactivity disorder (ADHD) is a major public health concern. It has been suggested that the brain’s default network may provide a crucial avenue for understanding the neurobiology of ADHD. Evaluations of the default network have increased over recent years with the applied technique of resting-state functional connectivity MRI (rs-fcMRI). These investigations have established that spontaneous activity in this network is highly correlated at rest in young adult populations. This coherence seems to be reduced in adults with ADHD. This is an intriguing finding, as coherence in spontaneous activity within the default network strengthens with age. Thus, the pathophysiology of ADHD might include delayed or disrupted maturation of the default network. If so, it is important to determine whether an altered developmental picture can be detected using rs-fcMRI in children with ADHD. The present study utilized the typical developmental context provided previously by Fair et al to examine coherence of brain activity within the default network using rs-fcMRI in children with (n=23) and without ADHD (n=23). We found that functional connections previously shown as developmentally dynamic in the default network were atypical in children with ADHD - consistent with perturbation or failure of the maturational processes. These findings are consistent with the hypothesis that atypical consolidation of this network over development plays a role in ADHD.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
患有和不患有注意力缺陷多动障碍（ADHD）的青少年在执行持续注意力任务期间大脑激活随时间的差异模式。
影响因子：
1.4
作者：
Epstein JN;Delbello MP;Adler CM;Altaye M;Kramer M;Mills NP;Strakowski SM;Holland S
通讯作者：
Holland S
影响因子：
3.7
作者：
Gilbert, Sam J.;Spengler, Stephanie;Burgess, Paul W.
通讯作者：
Burgess, Paul W.
影响因子：
14.5
作者：
Church, Jessica A.;Fair, Damien A.;Dosenbach, Nico U. F.;Cohen, Alexander L.;Miezin, Francis M.;Petersen, Steven E.;Schlaggar, Bradley L.
通讯作者：
Schlaggar, Bradley L.
影响因子：
2.4
作者：
Epstein, JN;Conners, CK;Swanson, JM
通讯作者：
Swanson, JM