Low maternal retinol as a risk factor for schizophrenia in adult offspring.
Low maternal retinol as a risk factor for schizophrenia in adult offspring.
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DOI：
10.1016/j.schres.2012.02.004
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发表时间：
2012-05
影响因子：
4.5
通讯作者：
Brown, Alan S.
中科院分区：
文献类型：
--
作者：
Bao, YuanYuan;Ibram, Ghionul;Blaner, William S.;Quesenberry, Charles P.;Shen, Ling;McKeague, Ian W.;Schaefer, Catherine A.;Susser, Ezra S.;Brown, Alan S.
关键词：
产前微量营养素缺乏与后代精神分裂症的后期发展有关；然而，没有研究专门调查维生素A和这种疾病之间的关系。维生素A是胚胎和胎儿早期基因表达和调控、细胞分化、增殖和迁移所必需的营养物质。先前的研究表明，妊娠中期维生素A缺乏可能与神经行为表型的发病机制特别相关，其中一些在精神分裂症中观察到。在精神分裂症的产前决定因素研究中，我们研究了妊娠中期母亲维生素A水平低是否与精神分裂症和其他精神分裂症谱系障碍（SSD）的风险相关；妊娠晚期还检测了维生素A水平与SSD的关系。这些病例来自一个以人口为基础的出生队列；所有队列成员都参加了预付费健康计划。对存档的产妇血清样本（55例）进行维生素A检测，每例（106例）最多2例对照（N=106），与健康计划的加入时间、出生日期（±28天）、性别、妊娠时间和存档的产妇血清的可用性相匹配。在妊娠中期，孕妇维生素A水平低（定义为在对照组中分布的最低五分位数）与SSD风险增加三倍以上相关，经产妇教育程度和年龄调整后（OR=3.04, 95% CI=1.06, 8.79, p= 0.039）。未观察到妊娠晚期孕妇维生素A与SSD之间的关联。虽然需要进一步的调查，但据我们所知，这是第一个报道母亲维生素A水平低与后代SSD之间关系的出生队列研究。
Prenatal micronutrient deficiency has been linked to later development of schizophrenia among offspring; however, no study has specifically investigated the association between vitamin A and this disorder. Vitamin A is an essential nutrient which is required by the early embryo and fetus for gene expression and regulation, cell differentiation, proliferation and migration. Previous work suggests that vitamin A deficiency in the second trimester may be particularly relevant to the etiopathogenesis of neurobehavioral phenotypes some of which are observed in schizophrenia. We examined whether low maternal vitamin A levels in the second trimester are associated with the risk of schizophrenia and other schizophrenia spectrum disorders (SSD) in the Prenatal Determinants of Schizophrenia study; third trimester vitamin A levels were also examined in relation to SSD. The cases were derived from a population-based birth cohort; all cohort members belonged to a prepaid health plan. Archived maternal serum samples were assayed for vitamin A in cases (N=55) and up to 2 controls per case (N=106) matched on length of membership in the health plan, date of birth (±28 days), sex, and gestational timing and availability of archived maternal sera. For the second trimester, low maternal vitamin A, defined as values in the lowest tertile of the distribution among controls, was associated with a greater than threefold increased risk of SSD, adjusting for maternal education and age (OR=3.04, 95% CI=1.06, 8.79, p=.039). No association between third trimester maternal vitamin A and SSD was observed. Although further investigations are warranted, this is the first birth cohort study to our knowledge to report an association between low maternal vitamin A levels and SSD among offspring.
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DOI：
10.1097/00042560-199704010-00003
发表时间：
1997-04-01
期刊：
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY
影响因子：
--
作者：
Burger, H;Kovacs, A;Blaner, WS
通讯作者：
Blaner, WS
影响因子：
2.5
作者：
Gazala, E;Sarov, B;Gorodischer, R
通讯作者：
Gorodischer, R
影响因子：
7.3
作者：
Alique, M.;Moreno, V.;Lucio-Cazana, F. J.
通讯作者：
Lucio-Cazana, F. J.
影响因子：
--
作者：
Insel, Beverly J.;Schaefer, Catherine A.;McKeague, Ian W.;Susser, Ezra S.;Brown, Alan S.
通讯作者：
Brown, Alan S.
影响因子：
6.7
作者：
Brown AS
通讯作者：
Brown AS