A randomized trial of cognitive rehabilitation in cancer survivors.
A randomized trial of cognitive rehabilitation in cancer survivors.
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DOI：
10.1016/j.lfs.2013.08.011
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发表时间：
2013-10-17
期刊：
影响因子：
6.1
通讯作者：
Willis, S. L.
中科院分区：
文献类型：
--
作者：
Cherrier, M. M.;Anderson, K.;David, D.;Higano, C. S.;Gray, H.;Church, A.;Willis, S. L.
癌症幸存者中第二个最常报告的治疗后症状是对认知受损的担忧。尽管许多研究表明，一部分幸存者存在严重损害，但关于有效治疗的信息仍然是一个新兴的研究领域。本研究探讨了基于小组的认知康复干预在癌症幸存者中的有效性。本研究是一项随机对照研究，以小组形式进行为期7周的认知康复干预。在治疗前和治疗后，对参与者进行主观症状问卷调查和客观神经认知测试。28名参与者（平均年龄58岁）完成了研究，主要/辅助治疗后中位时间为3年（+/-6年），不同癌症部位（乳腺癌、膀胱癌、前列腺癌、结肠癌、子宫癌）。与基线相比，治疗组表现出认知障碍症状（p<.01）、认知能力（p<.01）和认知症状方面的总体生活质量（p<.01）的改善，如FACT-Cog所测量的。治疗组的注意力客观指标也有所改善（p<0.05），非文字记忆也有改善的趋势。在所有认知测试中均未观察到显著改善。对癌症幸存者进行基于小组的认知康复干预，可有效改善与认知相关的注意力能力和整体生活质量。结果表明，基于小组的认知康复可能是治疗癌症患者认知功能障碍的有效干预措施，应在具有积极对照条件的更大规模试验中进一步研究。
The second most frequently reported post treatment symptom in cancer survivors is concerns about impaired cognition. Despite numerous studies demonstrating significant impairments in a portion of survivors, information on effective treatments remains an emerging area of research. This study examined the effectiveness of a group-based cognitive rehabilitation intervention in cancer survivors. This study was a randomized, controlled study of a 7-week cognitive rehabilitation intervention delivered in group format. Participants were evaluated with subjective symptom questionnaires and objective neurocognitive tests prior to and following treatment. Twenty-eight participants (mean age 58 yrs) with a median of 3 years (+/− 6 yrs) post primary/adjuvant treatment and various cancer sites (breast, bladder, prostate, colon, uterine) completed the study. Compared to baseline, the treatment group demonstrated improvements in symptoms of perceived cognitive impairments (p<.01), cognitive abilities (p<.01) and overall quality of life with regard to cognitive symptoms (p<.01) as measured by the FACT-Cog. The treatment group also improved on objective measures of attention (p<.05) and a trend toward improvement on verbal memory. Significant improvement was not observed on all cognitive tests. A group based cognitive rehabilitation intervention in cancer survivors was effective for improving attention abilities and overall quality of life related to cognition. Results suggest that group based cognitive rehabilitation may be an effective intervention for treating cognitive dysfunction in cancer patients and should be further studied in a larger trial with an active control condition..
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