Development of CBT for chemotherapy-related cognitive change: results of a waitlist control trial.
Development of CBT for chemotherapy-related cognitive change: results of a waitlist control trial.
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DOI：
10.1002/pon.1878
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发表时间：
2012-02
期刊：
影响因子：
3.6
通讯作者：
Saykin, Andrew J.
中科院分区：
文献类型：
--
作者：
Ferguson, Robert J.;McDonald, Brenna C.;Rocque, Michael A.;Furstenberg, Charlotte T.;Horrigan, Susan;Ahles, Tim A.;Saykin, Andrew J.
评估正在开发的用于管理乳腺癌幸存者化疗后认知功能障碍的简短认知行为疗法（CBT）的疗效。记忆和注意力适应训练（MAAT）是一种简短的CBT，旨在改善化疗后认知障碍的癌症幸存者的生活质量和功能。进行了一项初始的两组（MAAT与等待名单，无治疗对照）随机临床试验（RCT）。将40名I期和II期女性乳腺癌幸存者（平均年龄= 50岁; SD = 6.4）随机分配至不同条件，并在基线、治疗后（8周）和2个月随访评估点评估以下指标：（1）自我报告的日常认知功能障碍;（2）生活质量;（3）神经心理学表现。还评估了参与者对MAAT的满意度。以教育和智商为协变量，MAAT参与者在生活质量测量的精神健康子量表和口头记忆方面相对于对照组有了显着改善，但在日常认知投诉的自我报告方面没有达到统计学显著性。然而，在这些结果中观察到中到大效应量。参与者对MAAT的满意度很高。虽然这项最初的RCT是一项小型研究，但MAAT参与者似乎在一项生活质量和非文字记忆表现指标上有所改善，相对于无治疗对照组，MAAT满意度较高。这些数据令人鼓舞，并支持MAAT疗效的持续开发和评价。
To evaluate the efficacy of a brief cognitive-behavioral therapy (CBT) that is being developed for management of cognitive dysfunction following chemotherapy among breast cancer survivors. Memory and Attention Adaptation Training (MAAT) is a brief CBT designed to improve the quality of life and function among cancer survivors with post-chemotherapy cognitive complaints. An initial, two-group (MAAT versus waitlist, no treatment control), randomized clinical trial (RCT) was conducted. Forty stage I and II female breast cancer survivors (mean age = 50; SD = 6.4) were randomized to conditions and assessed at baseline, post-treatment (8 weeks) and 2-month follow-up assessment points on measures of: (1) self-reported daily cognitive failures; (2) quality of life; and (3) neuropsychological performance. Participants were also assessed for satisfaction with MAAT. With education and IQ as covariates, MAAT participants made significant improvements relative to controls on the spiritual well-being subscale of the quality of life measure and on verbal memory, but statistical significance was not achieved on self-report of daily cognitive complaints. However, moderate-to-large effect sizes were observed on these outcomes. Participants gave MAAT high satisfaction ratings. Although this initial RCT is a small study, MAAT participants appear to improve on one measure of quality of life and verbal memory performance relative to no treatment controls and rate MAAT with high satisfaction. These data are encouraging and support the continued development and evaluation of MAAT efficacy.
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影响因子：
5.8
作者：
Lustig, Cindy;Shah, Priti;Seidler, Rachael;Reuter-Lorenz, Patricia A.
通讯作者：
Reuter-Lorenz, Patricia A.
影响因子：
45.3
作者：
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影响因子：
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作者：
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影响因子：
4.7
作者：
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通讯作者：
Jacobsen, P
影响因子：
45.3
作者：
Ahles, TA;Saykin, AJ;Silberfarb, PM
通讯作者：
Silberfarb, PM