Host Factors in Coronavirus Replication.
Host Factors in Coronavirus Replication.
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DOI：
10.1007/82_2017_25
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发表时间：
2018
影响因子：
--
通讯作者：
van Hemert MJ
中科院分区：
文献类型：
--
作者：
de Wilde AH;Snijder EJ;Kikkert M;van Hemert MJ
冠状病毒是对人类和动物健康的严重影响的病原体。致病性冠状病毒，我们预防或治疗冠状病毒感染的选择非常有限。细胞贡献通过与宿主细胞相互作用，通过改变宿主基因表达或抵消宿主的抗病毒防御量来创造冠状病毒细胞的相互作用。 Avirus复制仍处于早期阶段与其他一些 +RNA病毒相比，该评论总结了我们当前对感染细胞水平的冠状病毒 - 宿主相互作用的理解，并特别注意病毒RNA合成机制的组装和功能和功能。
Coronaviruses are pathogens with a serious impact on human and animal health. They mostly cause enteric or respiratory disease, which can be severe and life threatening, e.g., in the case of the zoonotic coronaviruses causing severe acute respiratory syndrome (SARS) and Middle East Respiratory Syndrome (MERS) in humans. Despite the economic and societal impact of such coronavirus infections, and the likelihood of future outbreaks of additional pathogenic coronaviruses, our options to prevent or treat coronavirus infections remain very limited. This highlights the importance of advancing our knowledge on the replication of these viruses and their interactions with the host. Compared to other +RNA viruses, coronaviruses have an exceptionally large genome and employ a complex genome expression strategy. Next to a role in basic virus replication or virus assembly, many of the coronavirus proteins expressed in the infected cell contribute to the coronavirus-host interplay. For example, by interacting with the host cell to create an optimal environment for coronavirus replication, by altering host gene expression or by counteracting the host’s antiviral defenses. These coronavirus–host interactions are key to viral pathogenesis and will ultimately determine the outcome of infection. Due to the complexity of the coronavirus proteome and replication cycle, our knowledge of host factors involved in coronavirus replication is still in an early stage compared to what is known for some other +RNA viruses. This review summarizes our current understanding of coronavirus–host interactions at the level of the infected cell, with special attention for the assembly and function of the viral RNA-synthesising machinery and the evasion of cellular innate immune responses.
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影响因子：
5.2
作者：
Chan SW
通讯作者：
Chan SW
DOI：
10.1007/978-1-4939-0888-2_10
发表时间：
2014
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
--
作者：
Bagga S;Bouchard MJ
通讯作者：
Bouchard MJ
影响因子：
13
作者：
Bruns, Annie M.;Horvath, Curt M.
通讯作者：
Horvath, Curt M.
影响因子：
5.4
作者：
Chen, CJ;Makino, S
通讯作者：
Makino, S
影响因子：
6.4
作者：
Angelini MM;Akhlaghpour M;Neuman BW;Buchmeier MJ
通讯作者：
Buchmeier MJ