Extensively drug-resistant Alcaligenes faecalis infection.
Extensively drug-resistant Alcaligenes faecalis infection.
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DOI：
10.1186/s12879-020-05557-8
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发表时间：
2020-11-11
影响因子：
3.7
通讯作者：
Huang C
中科院分区：
文献类型：
--
作者：
Huang C
粪产碱杆菌通常引起人类机会性感染。粪产碱杆菌感染通常难以治疗，因为它对几种抗生素的耐药性增加。对粪产碱杆菌感染患者的临床研究结果可能有助于改善患者的临床护理。我们对2014年1月至2019年12月期间出现粪产碱杆菌感染的所有患者进行了回顾性分析。审查所有患者的病历，了解人口统计学信息、临床症状和体征、合并症、过去三个月内静脉注射抗生素的使用情况、细菌培养、抗生素敏感性试验和临床结局。在研究期间观察到61例粪产碱杆菌感染，包括25例膀胱炎、9例糖尿病足感染、8例肺炎、7例急性肾盂肾炎、3例菌血症和9例特定部位感染。37名患者（60.7%）在诊断后3个月内有静脉注射抗生素的病史。51例（83.6%）合并其他细菌感染。自2018年以来，已报告了广泛耐药感染。2019年对粪产碱杆菌最佳敏感率为66.7%，为亚胺培南、美罗培南、头孢他啶三种抗生素。对环丙沙星和哌拉西林/他唑巴坦两种抗生素的敏感率分别为100%和100%。粪菌均低于50%。最常见的粪产碱杆菌感染部位依次为血流、泌尿道、皮肤和软组织以及中耳。粪产碱菌对常用抗生素的敏感率呈下降趋势。出现了广泛耐药的粪产碱杆菌感染。在线版本包含补充材料，可通过10.1186/s12879-020-05557-8获得。
Alcaligenes faecalis is usually causes opportunistic infections in humans. Alcaligenes faecalis infection is often difficult to treat due to its increased resistance to several antibiotics. The results from a clinical study of patients with Alcaligenes faecalis infection may help improve patients’ clinical care. We conducted a retrospective analysis of all patients presenting with Alcaligenes faecalis infection from January 2014 to December 2019. The medical records of all patients were reviewed for demographic information, clinical symptoms and signs, comorbidities, use of intravenous antibiotics within the past three months, bacterial culture, antibiotics sensitivity test, and clinical outcomes. Sixty-one cases of Alcaligenes faecalis infection were seen during the study period, including 25 cases of cystitis, nine cases of diabetic foot infection, eight cases of pneumonia, seven cases of acute pyelonephritis, three cases of bacteremia, and nine cases of infection at specific sites. Thirty-seven patients (60.7%) had a history of receiving intravenous antibiotics within three months of the diagnosis. Fifty-one (83.6%) cases were mixed with other bacterial infections. Extensively drug-resistant infections have been reported since 2018. The best sensitivity rate to Alcaligenes faecalis was 66.7% for three antibiotics (imipenem, meropenem, and ceftazidime) in 2019. Two antibiotics (ciprofloxacin and piperacillin/tazobactam) sensitivity rates to A. faecalis were less than 50%. The most frequent Alcaligenes faecalis infection sites, in order, are the bloodstream, urinary tract, skin and soft tissue, and middle ear. The susceptibility rate of Alcaligenes faecalis to commonly used antibiotics is decreasing. Extensively drug-resistant Alcaligenes faecalis infections have emerged. The online version contains supplementary material available at 10.1186/s12879-020-05557-8.
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