Candidate gene study of macular response to supplemental lutein and zeaxanthin.
Candidate gene study of macular response to supplemental lutein and zeaxanthin.
复制标题
候选基因研究对补充叶黄素和玉米黄素的黄斑反应。
DOI：
10.1016/j.exer.2013.07.020
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发表时间：
2013-10
影响因子：
3.4
通讯作者：
Hammond, Christopher J.
中科院分区：
文献类型：
--
作者：
Yonova-Doing, Ekaterina;Hysi, Pirro G.;Venturini, Cristina;Williams, Katie M.;Nag, Abhishek;Beatty, Stephen;Liew, S. H. Melissa;Gilbert, Clare E.;Hammond, Christopher J.
建议补充类胡萝卜素以防止年龄相关性黄斑变性。然而，视网膜黄斑色素反应存在相当大的变异性，这可能是由于潜在的遗传变异。本研究的目的是确定遗传因素是否也影响对补充剂的反应，这些遗传因素以前与视网膜或血清叶黄素中的横截面黄斑色素水平有关。为此，我们在来自TwinsUK队列的310名受试者中进行了8个候选基因的变体与补充前后血清叶黄素和视网膜黄斑色素光密度（MPOD）水平之间的关联研究。四种变体与对补充剂的MPOD反应相关（p < 0.05）：rs 11057841（SCARB 1）、rs 4926339（RPE 65）、rs 1929841（ABCA 1）和rs 174534（FADS 1）。我们还证实了先前BMCO 1附近的rs6564851（p < 0.001）和SCARB 1内的rs 11057841（p = 0.01）与血清叶黄素基线测量值之间的相关性;虽然后者也与MPOD反应相关，但BMCO 1变异体均不相关。最后，有证据表明，RPE 65和BMPVL 2附近的变异体与补充后叶黄素浓度的变化之间存在关联。这项研究是第一个显示遗传变异和对类胡萝卜素补充反应之间的关联。我们的研究结果表明，MP响应和类胡萝卜素运输和脂肪酸代谢的生物过程之间的重要联系。四种变异与黄斑色素对补充剂的反应有关。我们复制了BMCO 1变异体与基线时叶黄素之间的关联。类胡萝卜素转运可能影响黄斑对补充剂的反应。脂质代谢可能影响黄斑对补充剂的反应。
Supplementation with carotenoids is proposed to protect against age-related macular degeneration. There is, however, considerable variability in retinal macular pigment response, which may be due to underlying genetic variation. The purpose of this study was to determine whether genetic factors, which have been previously associated with cross-sectional macular pigment levels in the retina or serum lutein, also influence response to supplementation. To this end we conducted an association study in 310 subjects from the TwinsUK cohort between variants in 8 candidate genes and serum lutein and retinal macular pigment optical density (MPOD) levels before and after supplementation. Four variants were associated with MPOD response to supplementation (p < 0.05): rs11057841 (SCARB1), rs4926339 (RPE65), rs1929841 (ABCA1) and rs174534 (FADS1). We also confirmed previous associations between rs6564851 near BMCO1 (p < 0.001) and rs11057841 within SCARB1 (p = 0.01) and baseline measures of serum lutein; while the latter was also associated with MPOD response, none of the BMCO1 variants were. Finally, there was evidence for association between variants near RPE65 and ELOVL2 and changes in lutein concentration after supplementation. This study is the first to show association between genetic variants and response to carotenoids supplementation. Our findings suggest an important link between MP response and the biological processes of carotenoids transport and fatty acid metabolism. Four variants were associated with macular pigment response to supplementation. We replicated associations between BMCO1 variants and lutein at baseline. Carotenoids transport may affect macular response to supplementation. Lipid metabolism may affect macular response to supplementation.
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影响因子：
7.1
作者：
KOSTIC, D;WHITE, WS;OLSON, JA
通讯作者：
OLSON, JA
影响因子：
3.5
作者：
Cipriani, Valentina;Leung, Hin-Tak;Yates, John R. W.
通讯作者：
Yates, John R. W.
影响因子：
17.8
作者：
Margrain, TH;Boulton, M;Sliney, DH
通讯作者：
Sliney, DH
DOI：
10.1016/s1383-5718(03)00155-4
发表时间：
2003-08-05
影响因子：
1.9
作者：
Klamt, F;Dal-Pizzol, F;Moreira, JCF
通讯作者：
Moreira, JCF
影响因子：
30.8
作者：
Fritsche, Lars G.;Chen, Wei;Schu, Matthew;Yaspan, Brian L.;Yu, Yi;Thorleifsson, Gudmar;Zack, Donald J.;Arakawa, Satoshi;Cipriani, Valentina;Ripke, Stephan;Igo, Robert P., Jr.;Buitendijk, Gabrielle H. S.;Sim, Xueling;Weeks, Daniel E.;Guymer, Robyn H.;Merriam, Joanna E.;Francis, Peter J.;Hannum, Gregory;Agarwal, Anita;Armbrecht, Ana Maria;Audo, Isabelle;Aung, Tin;Barile, Gaetano R.;Benchaboune, Mustapha;Bird, Alan C.;Bishop, Paul N.;Branham, Kari E.;Brooks, Matthew;Brucker, Alexander J.;Cade, William H.;Cain, Melinda S.;Campochiaroll, Peter A.;Chan, Chi-Chao;Cheng, Ching-Yu;Chew, Emily Y.;Chin, Kimberly A.;Chowers, Itay;Clayton, David G.;Cojocaru, Radu;Conley, Yvette P.;Cornes, Belinda K.;Daly, Mark J.;Dhillon, Baljean;Edwards, Albert;Evangelou, Evangelos;Fagemess, Jesen;Ferreyra, Henry A.;Friedman, James S.;Geirsdottir, Asbjorg;George, Ronnie J.;Gieger, Christian;Gupta, Neel;Hagstrom, Stephanie A.;Harding, Simon P.;Haritoglou, Christos;Heckenlively, John R.;Hoz, Frank G.;Hughes, Guy;Ioannidis, John P. A.;Ishibashi, Tatsuro;Joseph, Peronne;Jun, Gyungah;Kamatani, Yoichiro;Katsanis, Nicholas;Keilhauer, Claudia N.;Khan, Jane C.;Kim, Ivana K.;Kiyohara, Yutaka;Klein, Barbara E. K.;Klein, Ronald;Kovach, Jaclyn L.;Kozak, Igor;Lee, Clara J.;Lee, Kristine E.;Lichtner, Peter;Lotery, Andrew J.;Meitinger, Thomas;Mitchell, Paul;Mohand-Saied, Saddek;Moore, Anthony T.;Morgan, Denise J.;Morrison, Margaux A.;Myers, Chelsea E.;Naj, Adam C.;Nakamura, Yusuke;Okada, Yukinori;Orlin, Anton;Ortube, M. Carolina;Othman, Mohammad I.;Pappas, Chris;Park, Kyu Hyung;Pauer, Gayle J. T.;Peachey, Neal S.;Poch, Olivier;Priya, Rinki Ratna;Reynolds, Robyn;Richardson, Andrea J.;Ripp, Raymond;Rudolph, Guenther;Ryu, Euijung;Sahel, Jose-Alain;Schaumberg, Debra A.;Scholl, Hendrik P. N.;Schwartz, Stephen G.;Scott, William K.;Shahid, Humma;Sigurdsson, Haraldur;Silvestri, Giuliana;Sivakumaran, Theru A.;Smith, R. Theodore;Sobrin, Lucia;Souied, Eric H.;Stambolian, Dwight E.;Stefansson, Hreinn;Sturgill-Short, Gwen M.;Takahashi, Atsushi;Tosakulwong, Nirubol;Truitt, Barbara J.;Tsironi, Evangelia E.;Uitterlinden, Andre G.;van Duijn, Cornelia M.;Vijaya, Lingam;Vingerling, Johannes R.;Vithana, Eranga N.;Webster, Andrew R.;Wichmann, H-Erich;Winkler, Thomas W.;Wong, Tien Y.;Wright, Alan F.;Zelenika, Diana;Zhang, Ming;Zhao, Ling;Zhang, Kang;Klein, Michael L.;Hageman, Gregory S.;Lathrop, G. Mark;Stefansson, Kari;Allikmets, Rando;Baird, Paul N.;Gorin, Michael B.;Wang, Jie Jin;Klaver, Caroline C. W.;Seddon, Johanna M.;Pericak-Vance, Margaret A.;Iyengar, Sudha K.;Yates, John R. W.;Swaroop, Anand;Weber, Bernhard H. F.;Kubo, Michiaki;DeAngelis, Margaret M.;Leveillard, Thierry;Thorsteinsdottir, Unnur;Haines, Jonathan L.;Farrer, Lindsay A.;Heid, Iris M.;Abecasis, Goncalo R.
通讯作者：
Abecasis, Goncalo R.