Bone resorption and incretin hormones following glucose ingestion in healthy emerging adults.
Bone resorption and incretin hormones following glucose ingestion in healthy emerging adults.
复制标题
DOI：
10.1016/j.jcte.2023.100314
复制
发表时间：
2023-03
影响因子：
3
通讯作者：
Kindler, Joseph M.
中科院分区：
文献类型：
--
作者：
Lei, Wang Shin;Rodrick, Eugene B.;Belcher, Staci L.;Kelly, Andrea;Kindler, Joseph M.
葡萄糖的摄入对健康的新生成年人产生了急性骨吸收作用。胰高血糖素样肽 1 (GLP-1) 是一种参与餐后胰岛素产生的肠促胰岛素激素，与骨代谢和骨微结构的生物标志物的变化有关。 “肠骨轴”是一种潜在机制，会在骨量峰值周围的年份影响骨生成。成人研究表明，大量营养素的摄入会对骨产生急性抗骨吸收作用，反映在骨吸收生物标志物 C 末端端肽 (CTX) 的减少，而肠源性肠促胰岛素激素、葡萄糖依赖性促胰岛素多肽 (GIP) 和胰高血糖素样肽 1 (GLP-1) 会促进这种反应。关于骨转换的其他生物标志物以及肠骨串扰在达到峰值骨强度的几年中是否起作用，仍然存在知识差距。这项研究首先描述了口服葡萄糖耐量试验 (OGTT) 期间骨吸收的变化，其次测试了 OGTT 期间肠促胰岛素和骨生物标志物变化与骨微结构之间的关系。我们对 10 名年龄在 18 至 25 岁之间的健康新兴成年人进行了一项横断面研究。在多样本 2 小时 75 g OGTT 过程中，在第 0、30、60 和 120 分钟测定葡萄糖、胰岛素、GIP、GLP-1、CTX、骨特异性碱性磷酸酶 (BSAP)、骨钙素、骨保护素 (OPG)、核因子 kappa-β 配体受体激活剂 (RANKL)、硬化素和甲状旁腺激素 (PTH)。曲线下增量面积 (iAUC) 是根据 0-30 分钟和 0-120 分钟计算的。使用第二代高分辨率外周定量计算机断层扫描评估胫骨骨微结构。 OGTT 期间，葡萄糖、胰岛素、GIP 和 GLP-1 显着增加。第 30、60 和 120 分钟的 CTX 显着低于第 0 分钟，到第 120 分钟最大下降约 53%。葡萄糖-iAUC0-30 与 CTX-iAUC0-120 呈负相关（rho = -0.91，P < 0.001），GLP-1-iAUC0-30 与 CTX-iAUC0-30 呈正相关。 BSAP-iAUC0-120（rho = 0.83，P = 0.005）、RANKL-iAUC0-120（rho = 0.86，P = 0.007）和皮质体积骨矿物质密度（rho = 0.93，P < 0.001）。在骨强度峰值前后的几年里，葡萄糖的摄入会对骨代谢产生抗吸收作用。在这个关键的生命阶段，肠道和骨骼之间的相互作用需要进一步关注。
Glucose ingestion yielded an acute bone anti-resorptive effect in healthy emerging adults. Glucagon-like peptide 1 (GLP-1), an incretin hormone involved in post-prandial insulin production, was associated with changes in biomarkers of bone metabolism and bone microarchitecture. The ‘gut-bone axis’ is a potential mechanism that influences bone accrual during the years surrounding peak bone mass. Studies in adults indicate that macronutrient ingestion yields an acute anti-resorptive effect on bone, reflected by decreases in C-terminal telopeptide (CTX), a biomarker of bone resorption, and that gut-derived incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), facilitate this response. There remain knowledge gaps relating to other biomarkers of bone turnover, and whether gut-bone cross-talk is operative during the years surrounding peak bone strength attainment. This study first, describes changes in bone resorption during oral glucose tolerance testing (OGTT), and second, tests relationships between changes in incretins and bone biomarkers during OGTT and bone micro-structure. We conducted a cross-sectional study in 10 healthy emerging adults ages 18–25 years. During a multi-sample 2-hour 75 g OGTT, glucose, insulin, GIP, GLP-1, CTX, bone-specific alkaline phosphatase (BSAP), osteocalcin, osteoprotegerin (OPG), receptor activator of nuclear factor kappa-β ligand (RANKL), sclerostin, and parathyroid hormone (PTH) were assayed at mins 0, 30, 60, and 120. Incremental areas under the curve (iAUC) were computed from mins 0–30 and mins 0–120. Tibia bone micro-structure was assessed using second generation high resolution peripheral quantitative computed tomography. During OGTT, glucose, insulin, GIP, and GLP-1 increased significantly. CTX at min 30, 60, and 120 was significantly lower than min 0, with a maximum decrease of about 53 % by min 120. Glucose-iAUC0-30 inversely correlated with CTX-iAUC0-120 (rho = -0.91, P < 0.001), and GLP-1-iAUC0-30 positively correlated with BSAP-iAUC0-120 (rho = 0.83, P = 0.005), RANKL-iAUC0-120 (rho = 0.86, P = 0.007), and cortical volumetric bone mineral density (rho = 0.93, P < 0.001). Glucose ingestion yields an anti-resorptive effect on bone metabolism during the years surrounding peak bone strength. Cross-talk between the gut and bone during this pivotal life stage requires further attention.
登录
查看更多内容
影响因子：
4.1
作者：
Helsted, Mads M.;Gasbjerg, Laerke S.;Knop, Filip K.
通讯作者：
Knop, Filip K.
影响因子：
4.1
作者：
Bjarnason, NH;Henriksen, EEG;Christiansen, C
通讯作者：
Christiansen, C
影响因子：
6.2
作者：
Henriksen, DB;Alexandersen, P;Christiansen, C
通讯作者：
Christiansen, C
影响因子：
3.2
作者：
Chailurkit, La-or;Chanprasertyothin, Suwannee;Ongphiphadhanakul, Boonsong
通讯作者：
Ongphiphadhanakul, Boonsong
影响因子：
5.8
作者：
Kontulainen, Saija A.;Macdonald, Heather M.;Mckay, Heather A.
通讯作者：
Mckay, Heather A.