A disinhibitory microcircuit initiates critical-period plasticity in the visual cortex.
A disinhibitory microcircuit initiates critical-period plasticity in the visual cortex.
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作者：
早期感觉经验指导皮层神经回路的成熟。这已经在初级视觉皮层中得到了广泛的研究，其中一只眼睛的视力丧失永久地降低了对该眼睛的皮层反应性，这种现象被称为眼优势可塑性（ODP）。皮层抑制介导了这一过程，但特定类别的抑制性神经元在ODP中的确切作用是有争议的。在这里，我们报告说，在初级视觉皮层的双眼兴奋性神经元的诱发放电率立即下降了一半，当视力被限制在一只眼睛，但逐渐恢复正常，在接下来的24小时，尽管事实上，视力仍然限制在一只眼睛。单眼剥夺后双眼样兴奋性放电率的这种恢复是由于快速发放的小清蛋白阳性（PV）中间神经元的放电率快速但短暂地降低，这反过来又可以归因于PV中间神经元的局部兴奋性回路输入减少。单眼眼睑缝合后PV细胞诱发反应的减少仅限于ODP的关键期，并且似乎是兴奋性ODP随后变化所必需的。在视觉剥夺时的药理学增强抑制阻断ODP，并且相反地，PV细胞放电率的药理学遗传降低可以延长ODP的关键期。这些发现定义了在皮质发育的关键时期，微电路的变化引发了竞争性可塑性。此外，他们表明，通过PV特异性去抑制恢复L2/3锥体神经元的诱发放电率是眼优势可塑性进展的关键步骤。
Early sensory experience instructs the maturation of neural circuitry in cortex . This has been extensively studied in the primary visual cortex where loss of vision to one eye permanently degrades cortical responsiveness to that eye , a phenomenon known as ocular dominance plasticity (ODP). Cortical inhibition mediates this process , but the precise role of specific classes of inhibitory neurons in ODP is controversial. Here we report that evoked firing rates of binocular excitatory neurons in primary visual cortex immediately drop by half when vision is restricted to one eye, but gradually return to normal over the following 24 hours, despite the fact that vision remains restricted to one eye. This restoration of binocular-like excitatory firing rates following monocular deprivation results from a rapid, though transient reduction in the firing rates of fast-spiking, parvalbumin-positive (PV) interneurons, which in turn can be attributed to a decrease in local excitatory circuit input onto PV interneurons. This reduction in PV cell evoked responses following monocular lid suture is restricted to the critical period for ODP and appears to be necessary for subsequent shifts in excitatory ODP. Pharmacologically enhancing inhibition at the time of sight deprivation blocks ODP and, conversely, pharmaco-genetic reduction of PV cell firing rates can extend the critical period for ODP. These findings define the microcircuit changes initiating competitive plasticity during critical periods of cortical development. Moreover, they show that the restoration of evoked firing rates of L2/3 pyramidal neurons by PV-specific disinhibition is a key step in the progression of ocular dominance plasticity.
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DOI：
10.1073/pnas.0700293104
发表时间：
2007-03-20
影响因子：
11.1
作者：
Armbruster, Blaine N.;Li, Xiang;Roth, Bryan L.
通讯作者：
Roth, Bryan L.
影响因子：
25
作者：
Li, Haohong;Penzo, Mario A.;Taniguchi, Hiroki;Kopec, Charles D.;Huang, Z. Josh;Li, Bo
通讯作者：
Li, Bo
影响因子：
14.8
作者：
Holtmaat, Anthony;Bonhoeffer, Tobias;Chow, David K.;Chuckowree, Jyoti;De Paola, Vincenzo;Hofer, Sonja B.;Huebener, Mark;Keck, Tara;Knott, Graham;Lee, Wei-Chung A.;Mostany, Ricardo;Mrsic-Flogel, Tom D.;Nedivi, Elly;Portera-Cailliau, Carlos;Svoboda, Karel;Trachtenberg, Joshua T.;Wilbrecht, Linda
通讯作者：
Wilbrecht, Linda
DOI：
10.1523/jneurosci.4502-12.2013
发表时间：
2013-05-15
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Lambo ME;Turrigiano GG
通讯作者：
Turrigiano GG
影响因子：
5.3
作者：
Kameyama, Katsuro;Sohya, Kazuhiro;Tsumoto, Tadaharu
通讯作者：
Tsumoto, Tadaharu